About this Journal Submit a Manuscript Table of Contents
Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 296031, 7 pages
http://dx.doi.org/10.1155/2013/296031
Research Article

Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

1Immune Regulation and Tolerance Research Group, Programa Disciplinario de Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Santiago, Chile
2Millennium Institute on Immunology and Immunotherapy-Chile (P09-016-F), Santiago, Chile

Received 27 January 2013; Revised 7 May 2013; Accepted 13 May 2013

Academic Editor: Beatrice Gaugler

Copyright © 2013 Corina Peña et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. Steinman, D. Hawiger, and M. C. Nussenzweig, “Tolerogenic dendritic cells,” Annual Review of Immunology, vol. 21, pp. 685–711, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Steinbrink, M. Wölfl, H. Jonuleit, J. Knop, and A. H. Enk, “Induction of tolerance by IL-10-treated dendritic cells,” The Journal of Immunology, vol. 159, no. 10, pp. 4772–4780, 1997. View at Scopus
  3. A. E. Anderson, B. L. Sayers, M. A. Haniffa et al., “Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells,” Journal of Leukocyte Biology, vol. 84, no. 1, pp. 124–133, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Chorny, E. Gonzalez-Rey, A. Fernandez-Martin, D. Pozo, D. Ganea, and M. Delgado, “Vasoactive intestinal peptide induces regulatory dendritic cells with therapeutic effects on autoimmune disorders,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 38, pp. 13562–13567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Menges, S. Rößner, C. Voigtländer et al., “Repetitive injections of dendritic cells matured with tumor necrosis factor α induce antigen-specific protection of mice from autoimmunity,” Journal of Experimental Medicine, vol. 195, no. 1, pp. 15–21, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Salazar, O. Aravena, P. Abello et al., “Modulation of established murine collagen-induced arthritis by a single inoculation of short-term lipopolysaccharide-stimulated dendritic cells,” Annals of the Rheumatic Diseases, vol. 67, no. 9, pp. 1235–1241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. L. M. van Duivenvoorde, W. G. H. Han, A. M. Bakker et al., “Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms,” The Journal of Immunology, vol. 179, no. 3, pp. 1506–1515, 2007. View at Scopus
  8. D. Garate, N. Rojas-Colonelli, C. Pena, et al., “Blocking of p38 and transforming growth factor beta receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis,” Arthritis & Rheumatism, vol. 65, no. 1, pp. 120–129, 2013. View at Publisher · View at Google Scholar
  9. T. Hügle and J. M. van Laar, “Stem cell transplantation for rheumatic autoimmune diseases,” Arthritis Research and Therapy, vol. 10, no. 5, article 217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Buttgereit, K. G. Saag, M. Cutolo, J. A. P. da Silva, and J. W. J. Bijlsma, “The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis,” Scandinavian Journal of Rheumatology, vol. 34, no. 1, pp. 14–21, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Wilckens and R. de Rijk, “Glucocorticoids and immune function: unknown dimensions and new frontiers,” Immunology Today, vol. 18, no. 9, pp. 418–424, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Chen, T. Murakami, J. J. Oppenheim, and O. M. Z. Howard, “Differential response of murine CD4+CD25+ and CD4+CD25- T cells to dexamethasone-induced cell death,” European Journal of Immunology, vol. 34, no. 3, pp. 859–869, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Karagiannidis, M. Akdis, P. Holopainen et al., “Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma,” The Journal of Allergy and Clinical Immunology, vol. 114, no. 6, pp. 1425–1433, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Prado, J. Gómez, P. López, B. de Paz, C. Gutiérrez, and A. Suárez, “Dexamethasone upregulates FOXP3 expression without increasing regulatory activity,” Immunobiology, vol. 216, no. 3, pp. 386–392, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Hua, L. Ji, Y. Zhan, et al., “Pulsed high-dose dexamethasone improves interleukin 10 secretion by CD5+ B cells in patients with primary immune thrombocytopenia,” Journal of Clinical Immunology, vol. 32, no. . 6, pp. 1233–1242, 2012. View at Publisher · View at Google Scholar
  16. M. H. Blotta, R. H. DeKruyff, and D. T. Umetsu, “Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes,” The Journal of Immunology, vol. 158, no. 12, pp. 5589–5595, 1997. View at Scopus
  17. E. C. de Jong, P. L. Vieira, P. Kalinski, and M. L. Kapsenberg, “Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3,” Journal of Leukocyte Biology, vol. 66, no. 2, pp. 201–204, 1999. View at Scopus
  18. J. Pan, D. Ju, Q. Wang et al., “Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway,” Immunology Letters, vol. 76, no. 3, pp. 153–161, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Flierman, H. J. Witteveen, E. I. H. van der Voort et al., “Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation,” Blood, vol. 105, no. 7, pp. 2991–2994, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. L. E. Harrington, P. R. Mangan, and C. T. Weaver, “Expanding the effector CD4 T-cell repertoire: the Th17 lineage,” Current Opinion in Immunology, vol. 18, no. 3, pp. 349–356, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. A. E. Anderson, D. J. Swan, B. L. Sayers et al., “LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells,” Journal of Leukocyte Biology, vol. 85, no. 2, pp. 243–250, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Bax, S. J. van Vliet, M. Litjens, J. J. García-Vallejo, and Y. van Kooyk, “Interaction of polysialic acid with CCL21 regulates the migratory capacity of human dendritic cells,” PLoS ONE, vol. 4, no. 9, Article ID e6987, 2009. View at Publisher · View at Google Scholar · View at Scopus