Upregulated MicroRNA-155 Expression in Peripheral Blood Mononuclear Cells and Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Figure 3
Constitutive expression and inductive expression of miR-155 in RA-FLS. (a) Overexpression of miR-155 in cultured RA-FLS () compared to OA-FLS (, , 1.79 ± 1.94, 0.11 ± 0.17, resp.). (b) Trend of up-regulation by TNF-α on RA-FLS (). The up-regulation of miR-155 upon stimulation of RA-FLS, as compared with that in unstimulated control cultures, was about 1.87-fold with TNF-α stimulation, after 24 hours (); 2.22-fold after 48 hours (); and 1.38-fold after 72 hours ().