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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 320509, 6 pages
IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense
1Jomo Kenyatta University of Agriculture and Technology, College of Health Sciences, Biochemistry Department, P.O. Box 62000-00200, Nairobi, Kenya
2Institute of Primate Research, Animal Science Department, P.O. Box 24481-00502, Nairobi, Kenya
3Jomo Kenyatta University of Agriculture and Technology, College of Agriculture and Natural Resources, Animal Health and Production Department, P.O. Box 62000-00200, Nairobi, Kenya
Received 23 April 2013; Revised 27 August 2013; Accepted 2 September 2013
Academic Editor: Carlos Barcia
Copyright © 2013 Dawn Nyawira Maranga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- WHO, “African Trypanosomiasis,” World Health Organisation, Geneva, Switzerland, Fact Sheet No. 259, 2000.
- J. M. Kagira, N. Maina, J. Njenga, S. M. Karanja, S. M. Karori, and J. M. Ngotho, “Prevalence and types of coinfections in sleeping sickness patients in Kenya (2000/2009),” Journal of Tropical Medicine, vol. 2011, Article ID 248914, 6 pages, 2011.
- J. Clerinx, E. Vlieghe, V. Asselman, S. van de Casteele, M. B. Maes, and V. Lejon, “Human African trypanosomiasis in a Belgian traveller returning from the Masai Mara area, Kenya, February 2012,” Eurosurveillance, vol. 17, no. 10, article 3, 2012.
- T. Wolf, T. Wichelhaus, S. Göttig, C. Kleine, H. R. Brodt, and G. Just-Nuebling, “Trypanosoma brucei rhodesiense infection in a German traveller returning from the Masai Mara area, Kenya, January 2012,” Eurosurveillance, vol. 17, no. 10, article 2, 2012.
- WHO, “Control and Surveillance of African trypanosomiasis. Report of a WHO expert committee,” Tech. Rep. 114, World Health Organization, Geneva, Switzerland, 1998, Series. No. 8881.
- N. Tiberti, A. Hainard, V. Lejon et al., “Discovery and verification of osteopontin and beta-2-microglobulin as promising markers for staging human African trypanosomiasis,” Molecular and Cellular Proteomics, vol. 9, no. 12, pp. 2783–2795, 2010.
- N. Tiberti, A. Hainard, V. Lejon, et al., “Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of Trypanosoma brucei gambiense sleeping sickness,” PLoS ONE, vol. 7, no. 7, Article ID 40909, 2012.
- A. Hainard, N. Tiberti, X. Robin et al., “A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients,” PLoS Neglected Tropical Diseases, vol. 3, no. 6, article e459, 2009.
- A. Castellani, “On the discovery of a species of Trypanosoma in the cerebro-spinal fluid of cases of sleeping sickness,” Proceedings of the Royal Society of London B, vol. 71, pp. 501–508, 1903.
- A. A. Poltera, “Immunopathological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brain,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 74, no. 6, pp. 706–715, 1980.
- N. Quan, J. D. M. Mhlanga, M. B. Whiteside, et al., “Chronic overexpression of proinflammatory cytokines and histopathology in the brains of rats infected with Trypanosoma brucei,” Journal of Comparative Neurology, vol. 414, pp. 114–130, 1990.
- C. A. Hunter, F. W. Jennings, P. G. E. Kennedy, and M. Murray, “Astrocyte activation correlates with cytokine production in central nervous system of Trypanosoma brucei brucei-infected mice,” Laboratory Investigation, vol. 67, no. 5, pp. 635–642, 1992.
- H. Schmidt and P. Sayer, “Trypanosoma brucei rhodesiense infection in vervet monkeys. II. Provocation of the encephalitic late phase by treatment of infected monkeys,” Tropenmedizin und Parasitologie, vol. 33, no. 4, pp. 255–259, 1982.
- M. Ngotho, J. M. Kagira, A. K. Gaithuma, et al., “A robust and improved monkey model of human African trypanosomiasis,” in Proceedings of the 12th International Congress of Parasitology, pp. 39–46, Melbourne, Australia, August 2010.
- F. Maloba, J. Kagira, G. Gitau, et al., “Astrocytosis as a biomarker for late stage human African trypanosomiasis in the vervet monkey model,” Scientia Parasitologica, vol. 12, pp. 53–59, 2011.
- W. J. Herbert and W. H. R. Lumsden, “Trypanosoma brucei: a rapid “matching” method for estimating the host's parasitemia,” Experimental Parasitology, vol. 40, no. 3, pp. 427–431, 1976.
- B. Courtioux, C. Boda, G. Vatunga et al., “A link between chemokine levels and disease severity in human African trypanosomiasis,” International Journal for Parasitology, vol. 36, no. 9, pp. 1057–1065, 2006.
- S. Bisser, V. Lejon, P. M. Preux et al., “Blood-cerebrospinal fluid barrier and intrathecal immunoglobulins compared to field diagnosis of central nervous system involvement in sleeping sickness,” Journal of the Neurological Sciences, vol. 193, no. 2, pp. 127–135, 2002.
- M. Ngotho, N. Maina, J. Kagira, F. Royo, I. O. Farah, and J. Hau, “IL-10 is up regulated in early and transitional stages in vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense,” Parasitology International, vol. 55, no. 4, pp. 243–248, 2006.
- M. Ngotho, J. M. Kagira, H. E. Jensen, S. M. Karanja, I. O. Farah, and J. Hau, “Immunospecific immunoglobulins and IL-10 as markers for Trypanosoma brucei rhodesiense late stage disease in experimentally infected vervet monkeys,” Tropical Medicine and International Health, vol. 14, no. 7, pp. 736–747, 2009.
- J. M. Sternberg, J. Rodgers, B. Bradley, L. MacLean, M. Murray, and P. G. E. Kennedy, “Meningoencephalitic African trypanosomiasis: brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology,” Journal of Neuroimmunology, vol. 167, no. 1-2, pp. 81–89, 2005.
- L. MacLean, H. Reiber, P. G. Kennedy, et al., “Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response,” PLoS Neglected Tropical Diseases, vol. 6, no. 10, article e1857, 2012.
- V. Lejon, J. Lardon, G. Kenis et al., “Interleukin (IL)-6, IL-8 and IL-10 in serum and CSF of Trypanosoma brucei gambiense sleeping sickness patients before and after treatment,” Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 96, no. 3, pp. 329–333, 2002.
- Y. Dong and E. N. Benveniste, “Immune function of astrocytes,” GLIA, vol. 36, no. 2, pp. 180–190, 2001.
- P. G. E. Kennedy, “Human African trypanosomiasis of the CNS: current issues and challenges,” Journal of Clinical Investigation, vol. 113, no. 4, pp. 496–504, 2004.
- G. W. Goldstein, “Endothelial cell-astrocyte interactions. A cellular model of the blood-brain barrier,” Annals of the New York Academy of Sciences, vol. 529, pp. 31–39, 1988.
- N. J. Abbott, “Astrocyte-endothelial interactions and blood-brain barrier permeability,” Journal of Anatomy, vol. 200, no. 6, pp. 629–638, 2002.
- R. Paul, U. Koedel, F. Winkler et al., “Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis,” Brain, vol. 126, no. 8, pp. 1873–1882, 2003.
- N. Tiberti, E. Matovu, A. Hainard, et al., “New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients,” Clinical and Translational Medicine, vol. 2, pp. 123–125, 2013.