Pulmonary Innate Immune Response and Melatonin Receptors in the Perinatal Stress

Table 1

Comparison between the amounts of inflammatory markers and melatonin receptor in the lung.

Groups	N (%)	IL-6	IL1-β	TNF-α	CRP	Mel Rec
		X ± SD/median (minimum–maximum)
Chronic stress	32 (63.31)	25.37 (13.20–19.65)	1.42 (0.16–6.38)	2.90 (0.10–10.55)	9.45 (0.65–43.05)	5.95 (1.08–26.36)
Acute stress	17 (36.69)	4.30 (1.65–26.61)	1.19 (0.27–5.98)	3.59 (0.97–9.47)	0.63 (0.09–2.17)	2.79 (0.21–20.82)
		𝑇=212.000; 𝑃≤0.001	𝑇=340.000; 𝑃=0.809	𝑇=328.000; 𝑃=0.691	𝑇=52.000; 𝑃≤0.001	𝑇=308.000; 𝑃=0.028
Term	12 (24.49)	20.37 ± 14.00	1.12 (0.43–4.97)	3.59 ± 2.79	1.48 (0.34–16.62)	5.21 ± 3.29
Preterm	37 (75.51)	19.66 ± 9.98	1.42 (0.16–6.38)	3.96 ± 2.58	3.45 (0.09–43.05)	6.33 ± 5.99
		𝑡=0.194; 𝑃=0.847	𝑇=245.000; 𝑃=0.945	t = 0.411; 𝑃=0.683	𝑇=61.000; 𝑃=0.462	t = 0.614; 𝑃=0.543
Anoxia	20 (40.82)	25.51 ± 6.22*	1.59 (0.16–6.38)	2.99 (0.19–9.44)	3.62 (0.65–43.05)*	4.89 (1.08–17.84)
Infection	14 (28.57)	25.07 ± 7.45^#	1.33 (0.38–4.68)	2.83 (0.49–10.55)	10.19 (6.47–18.16)^#	7.58 (1.62–26.36)^#
Malformation	15 (30.61)	7.36 ± 8.13^*#	1.06 (0.27–5.98)	2.97 (0.97–9.47)	0.63 (0.09–2.17)^*#	2.51 (0.21–20.82)^#
		𝐹=32.483; 𝑃<0.001	𝐻=0.251; 𝑃=0.882	H = 0.924; 𝑃=0.630	𝐻=13.357; 𝑃=0.001	𝐻=12.489; 𝑃=0.002

CRP: C-reactive protein; Mel Rec: melatonin receptor. X ± SD: mean ± standard deviation; ^*#significant difference between groups by multiple comparison tests.