Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
Figure 5
Porous silicon microparticles loaded with antigens trigger the immune response. ELISPOT assays: the incubation of peripheral lymphocytes (PBMCs) from healthy donors with allogenic dendritic cells (MDDC) differentiated and matured in the presence of microparticles loaded with antigenic peptides (MSMP+) results in the activation of specific CD8 lymphocytes, showed as a synthesis of IFN-γ. PHA: phytohemagglutinin (1 μg); CEFpp: CEF peptide pool; MSMP(−): unloaded microparticles. *; ***.
