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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 371249, 14 pages
http://dx.doi.org/10.1155/2013/371249
Research Article

Investigation of Functional Activity of Cells in Granulomatous Inflammatory Lesions from Mice with Latent Tuberculous Infection in the New Ex Vivo Model

The Institute of Biochemistry of the Siberian Branch of the Russian Academy of Medical Sciences, 2 Timakova Street, Novosibirsk 630117, Russia

Received 3 June 2013; Revised 4 August 2013; Accepted 20 August 2013

Academic Editor: Jacek Tabarkiewicz

Copyright © 2013 Elena Ufimtseva. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. M. Parrish, J. D. Dick, and W. R. Bishai, “Mechanisms of latency in Mycobacterium tuberculosis,” Trends in Microbiology, vol. 6, no. 3, pp. 107–112, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. T. R. Frieden, T. R. Sterling, S. S. Munsiff, C. J. Watt, and C. Dye, “Tuberculosis,” Lancet, vol. 362, no. 9387, pp. 887–899, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. G. R. Stewart, B. D. Robertson, and D. B. Young, “Tuberculosis: a problem with persistence,” Nature Reviews, vol. 1, no. 2, pp. 97–105, 2003. View at Scopus
  4. J. L. Flynn, J. Chan, and P. L. Lin, “Macrophages and control of granulomatous inflammation in tuberculosis,” Mucosal Immunology, vol. 4, no. 3, pp. 271–278, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. B. M. Saunders and W. J. Britton, “Life and death in the granuloma: immunopathology of tuberculosis,” Immunology and Cell Biology, vol. 85, no. 2, pp. 103–111, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. L. Ramakrishnan, “Revisiting the role of the granuloma in tuberculosis,” Nature Reviews Immunology, vol. 12, no. 5, pp. 352–366, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. H. A. Schreiber and M. Sandor, “The role of dendritic cells in mycobacterium-induced granulomas,” Immunology Letters, vol. 130, no. 1-2, pp. 26–31, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Pieters, “Mycobacterium tuberculosis and the macrophage: maintaining a balance,” Cell Host and Microbe, vol. 3, no. 6, pp. 399–407, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Deretic, I. Vergne, J. Chua et al., “Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV,” Cellular Microbiology, vol. 6, no. 11, pp. 999–1009, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. A. L. K. Hestvik, Z. Hmama, and Y. Av-Gay, “Mycobacterial manipulation of the host cell,” Federation of European Microbiological Societies Microbiology Reviews, vol. 29, no. 5, pp. 1041–1050, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Behr, E. Schurr, and P. Gros, “TB: screening for responses to a vile visitor,” Cell, vol. 140, no. 5, pp. 615–618, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Ahmad, “Pathogenesis, immunology, and diagnosis of latent Mycobacterium tuberculosis infection,” Clinical and Developmental Immunology, vol. 2011, Article ID 814943, 17 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Rabson, I. M. Roitt, and P. J. Delves, Really Essential Medical Immunology, Blackwell, Oxford, UK, 2005.
  14. L. H. Hogan, W. Markofski, A. Bock, B. Barger, J. D. Morrissey, and M. Sandor, “Mycobacterium bovis BCG-induced granuloma formation depends on gamma interferon and CD40 ligand but does not require CD28,” Infection and Immunity, vol. 69, no. 4, pp. 2596–2603, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. L. H. Hogan, K. Macvilay, B. Barger et al., “Mycobacterium bovis strain bacillus calmette-guérin-induced liver granulomas contain a diverse TCR repertoire, but a monoclonal T cell population is sufficient for protective granuloma formation,” Journal of Immunology, vol. 166, no. 10, pp. 6367–6375, 2001. View at Scopus
  16. D. R. Roach, A. G. D. Bean, C. Demangel, M. P. France, H. Briscoe, and W. J. Britton, “TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection,” Journal of Immunology, vol. 168, no. 9, pp. 4620–4627, 2002. View at Scopus
  17. C. L. Fuller, J. L. Flynn, and T. A. Reinhart, “In situ study of abundant expression of proinflammatory chemokines and cytokines in pulmonary granulomas that develop in cynomolgus macaques experimentally infected with Mycobacterium tuberculosis,” Infection and Immunity, vol. 71, no. 12, pp. 7023–7034, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. P. C. Karakousis, T. Yoshimatsu, G. Lamichhane et al., “Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice,” Journal of Experimental Medicine, vol. 200, no. 5, pp. 647–657, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. M.-P. Puissegur, C. Botanch, J.-L. Duteyrat, G. Delsol, C. Caratero, and F. Altare, “An in vitro dual model of mycobacterial granulomas to investigate the molecular interactions between mycobacteria and human host cells,” Cellular Microbiology, vol. 6, no. 5, pp. 423–433, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. L. Flynn, “Lessons from experimental Mycobacterium tuberculosis infections,” Microbes and Infection, vol. 8, no. 4, pp. 1179–1188, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. C. Tsai, S. Chakravarty, G. Zhu et al., “Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension,” Cellular Microbiology, vol. 8, no. 2, pp. 218–232, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. B.-S. Yan, A. V. Pichugin, O. Jobe et al., “Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity,” Journal of Immunology, vol. 179, no. 10, pp. 6919–6932, 2007. View at Scopus
  23. R. E. Sacco, R. J. Jensen, C. O. Thoen et al., “Cytokine secretion and adhesion molecule expression by granuloma T lymphocytes in Mycobacterium avium infection,” American Journal of Pathology, vol. 148, no. 6, pp. 1935–1948, 1996. View at Scopus
  24. H. Clay, H. E. Volkman, and L. Ramakrishnan, “Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death,” Immunity, vol. 29, no. 2, pp. 283–294, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. D. M. Tobin and L. Ramakrishnan, “Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis,” Cellular Microbiology, vol. 10, no. 5, pp. 1027–1039, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. Davis and L. Ramakrishnan, “The role of the granuloma in expansion and dissemination of early tuberculous infection,” Cell, vol. 136, no. 1, pp. 37–49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. K. N. Adams, K. Takaki, L. E. Connolly et al., “Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism,” Cell, vol. 145, no. 1, pp. 39–53, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J. G. Egen, A. G. Rothfuchs, C. G. Feng, N. Winter, A. Sher, and R. N. Germain, “Macrophage and T cell dynamics during the development and disintegration of mycobacterial granulomas,” Immunity, vol. 28, no. 2, pp. 271–284, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. S. W. Edwards, D. A. Moulding, M. Derouet, and R. J. Moots, “Regulation of neutrophil apoptosis,” Chemical Immunology and Allergy, vol. 83, pp. 204–224, 2003. View at Scopus
  30. R. L. Hunter, M. Olsen, C. Jagannath, and J. K. Actor, “Trehalose 6,6′-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice,” American Journal of Pathology, vol. 168, no. 4, pp. 1249–1261, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. T. D. Bold and J. D. Ernst, “Who benefits from granulomas, mycobacteria or host?” Cell, vol. 136, no. 1, pp. 17–19, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Fortin, L. Abel, J. L. Casanova, and P. Gros, “Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis,” Annual Review of Genomics and Human Genetics, vol. 8, pp. 163–192, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Davis and L. Ramakrishnan, “‘The very pulse of the machine’: the tuberculous granuloma in motion,” Immunity, vol. 28, no. 2, pp. 146–148, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. D. N. J. Hart, “Dendritic cells: unique leukocyte populations which control the primary immune response,” Blood, vol. 90, no. 9, pp. 3245–3287, 1997. View at Scopus
  35. A. Mortellaro, L. Robinson, and R.-C. Paola, “Spotlight on mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge?” EMBO Molecular Medicine, vol. 1, no. 1, pp. 19–29, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. K. A. Prendergast and J. R. Kirman, “Dendritic cell subsets in mycobacterial infection: control of bacterial growth and T cell responses,” Tuberculosis, vol. 93, no. 2, pp. 115–122, 2013.
  37. H. L. Collins and S. H. E. Kaufmann, “The many faces of host responses to tuberculosis,” Immunology, vol. 103, no. 1, pp. 1–9, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. H. A. Schreiber, P. D. Hulseberg, J. Lee et al., “Dendritic cells in chronic mycobacterial granulomas restrict local anti-bacterial T cell response in a murine model,” PLoS One, vol. 5, no. 7, Article ID e11453, 2010. View at Publisher · View at Google Scholar · View at Scopus