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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 382698, 6 pages
FSH and TSH in the Regulation of Bone Mass: The Pituitary/Immune/Bone Axis
Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy
Received 1 March 2013; Revised 17 May 2013; Accepted 17 May 2013
Academic Editor: Giacomina Brunetti
Copyright © 2013 Graziana Colaianni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. N. Weitzmann and R. Pacifici, “Estrogen deficiency and bone loss: an inflammatory tale,” Journal of Clinical Investigation, vol. 116, no. 5, pp. 1186–1194, 2006.
- M. R. Sowers, M. Jannausch, D. McConnell et al., “Hormone predictors of bone mineral density changes during the menopausal transition,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 4, pp. 1261–1267, 2006.
- P. J. Menagh, R. T. Turner, D. B. Jump et al., “Growth hormone regulates the balance between bone formation and bone marrow adiposity,” Journal of Bone and Mineral Research, vol. 25, no. 4, pp. 757–768, 2010.
- P. R. Ebeling, “What is the missing hormonal factor controlling menopausal bone resorption?” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 11, pp. 4864–4866, 2010.
- D. C. Bauer, B. Ettinger, M. C. Nevitt, and K. L. Stone, “Risk for fracture in women with low serum levels of thyroid-stimulating hormone,” Annals of Internal Medicine, vol. 134, no. 7, pp. 561–568, 2001.
- D. Seriwatanachai, K. Thongchote, N. Charoenphandhu et al., “Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor κB ligand/osteoprotegerin ratio,” Bone, vol. 42, no. 3, pp. 535–546, 2008.
- R. Tamma, G. Colaianni, L. L. Zhu et al., “Oxytocin is an anabolic bone hormone,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 17, pp. 7149–7154, 2009.
- U. Omodei, G. Mazziotti, G. Donarini et al., “Effects of recombinant follicle-stimulating hormone on bone turnover markers in infertile women undergoing in vitro fertilization procedure,” The Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 1, pp. 330–336, 2013.
- M. R. Sowers, H. Zheng, D. McConnell, B. Nan, S. Harlow, and J. F. Randolph, “Follicle stimulating hormone and its rate of change in defining menopause transition stages,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 10, pp. 3958–3964, 2008.
- M. R. Sowers, J. S. Finkelstein, B. Ettinger et al., “The association of endogenous hormone concentrations and bone mineral density measures in pre- and perimenopausal women of four ethnic groups: SWAN,” Osteoporosis International, vol. 14, no. 1, pp. 44–52, 2003.
- J. C. Prior, “Perimenopause: the complex endocrinology of the menopausal transition,” Endocrine Reviews, vol. 19, pp. 397–428, 1998.
- L. Sun, Y. Peng, A. C. Sharrow et al., “FSH directly regulates bone mass,” Cell, vol. 125, no. 2, pp. 247–260, 2006.
- J. Gao, R. Tiwari-Pandey, R. Samadfam et al., “Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone,” Endocrinology, vol. 148, no. 6, pp. 2613–2621, 2007.
- N. Danilovich, P. S. Babu, W. Xing, M. Gerdes, H. Krishnamurthy, and M. R. Sairam, “Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice,” Endocrinology, vol. 141, no. 11, pp. 4295–4308, 2000.
- K. Sjögren, M. Lagerquist, S. Moverare-Skrtic et al., “Elevated aromatase expression in osteoblasts leads to increased bone mass without systemic adverse effects,” Journal of Bone and Mineral Research, vol. 24, no. 7, pp. 1263–1270, 2009.
- J. L. Hernandez, C. M. Garces, M. Sumillera et al., “Aromatase expression in osteoarthritic and osteoporotic bone,” Arthritis and Rheumatism, vol. 58, pp. 1696–1700, 2008.
- T. J. Martin and D. Gaddy, “Bone loss goes beyond estrogen,” Nature Medicine, vol. 12, pp. 612–613, 2006.
- R. Baron, “FSH versus estrogen: who’s guilty of breaking bones?” Cell Metabolism, vol. 3, pp. 302–305, 2006.
- V. Ritter, B. Thuering, P. Saint Mezard et al., “Follicle-stimulating hormone does not impact male bone mass in vivo or human male osteoclasts in vitro,” Calcified Tissue International, vol. 82, no. 5, pp. 383–391, 2008.
- M. L. Gourlay, B. L. Specker, C. Li, C. A. Hammett-Stabler, J. B. Renner, and J. E. Rubin, “Follicle-stimulating hormone is independently associated with lean mass but not BMD in younger postmenopausal women,” Bone, vol. 50, no. 1, pp. 311–316, 2012.
- M. T. Drake, L. K. McCready, K. A. Hoey, E. J. Atkinson, and S. Khosla, “Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 95, no. 11, pp. 5063–5068, 2010.
- C. M. Allan, R. Kalak, C. R. Dunstan et al., “Follicle-stimulating hormone increases bone mass in female mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 52, pp. 22629–22634, 2010.
- D. Rendina, F. Gianfrancesco, G. De Filippo et al., “FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women,” European Journal of Endocrinology, vol. 163, no. 1, pp. 165–172, 2010.
- C. J. Jagger, J. W. Chow, and T. J. Chambers, “Estrogen suppresses activation but enhances formation phase of osteogenic response to mechanical stimulation in rat bone,” The Journal of Clinical Investigation, vol. 98, pp. 2351–2357, 1996.
- G. Colaianni, L. Sun, A. Di Benedetto et al., “Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton,” The Journal of Biological Chemistry, vol. 287, no. 34, pp. 29159–29167, 2012.
- N. K. Shevde, A. C. Bendixen, K. M. Dienger, and J. W. Pike, “Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 14, pp. 7829–7834, 2000.
- S. Srivastava, G. Toraldo, M. N. Weitzmann, S. Cenci, F. P. Ross, and R. Pacifici, “Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-κB ligand (RANKL)-induced JNK activation,” Journal of Biological Chemistry, vol. 276, no. 12, pp. 8836–8840, 2001.
- C. Roggia, Y. Gao, S. Cenci et al., “Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 24, pp. 13960–13965, 2001.
- R. B. Kimble, S. Bain, and R. Pacifici, “The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice,” Journal of Bone and Mineral Research, vol. 12, no. 6, pp. 935–941, 1997.
- S. Cenci, M. N. Weitzmann, C. Roggia et al., “Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α,” Journal of Clinical Investigation, vol. 106, no. 10, pp. 1229–1237, 2000.
- P. D'Amelio, A. Grimaldi, S. Di Bella et al., “Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis,” Bone, vol. 43, no. 1, pp. 92–100, 2008.
- J. Iqbal, L. Sun, T. R. Kumar, H. C. Blair, and M. Zaidi, “Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 40, pp. 14925–14930, 2006.
- J. G. Cannon, M. Cortez-Cooper, E. Meaders et al., “Follicle-stimulating hormone, interleukin-1, and bone density in adult women,” American Journal of Physiology, vol. 298, no. 3, pp. R790–R798, 2010.
- J. G. Cannon, B. Kraj, and G. Sloan, “Follicle-stimulating hormone promotes RANK expression on human monocytes,” Cytokine, vol. 53, no. 2, pp. 141–144, 2011.
- P. D. Miller, “Guidelines for the diagnosis of osteoporosis: T-scores vs fractures,” Reviews in Endocrine & Metabolic Disorders, vol. 7, pp. 75–89, 2006.
- M. P. Akhter, J. M. Lappe, K. M. Davies, and R. R. Recker, “Transmenopausal changes in the trabecular bone structure,” Bone, vol. 41, no. 1, pp. 111–116, 2007.
- X. S. Liu, P. Sajda, P. K. Saha, F. W. Wehrli, and X. E. Guo, “Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone,” Journal of Bone and Mineral Research, vol. 21, no. 10, pp. 1608–1617, 2006.
- L. L. Zhu, H. Blair, J. Cao et al., “Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis,” Proceedings of the National Academy of Science of the United States of America, vol. 109, no. 36, pp. 14574–14579, 2012.
- M. W. Szkudlinski, V. Fremont, C. Ronin, and B. D. Weintraub, “Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships,” Physiological Reviews, vol. 82, no. 2, pp. 473–502, 2002.
- T. Davies, R. Marians, and R. Latif, “The TSH receptor reveals itself,” The Journal of Clinical Investigation, vol. 110, no. 2, pp. 161–164, 2002.
- D. T. Baran, “Thyroid hormone and bone mass: the clinician's dilemma,” Thyroid, vol. 4, no. 2, pp. 143–144, 1994.
- G. Mazziotti, T. Porcelli, I. Patelli, P. P. Vescovi, and A. Giustina, “Serum TSH values and risk of vertebral fractures in euthyroid post-menopausal women with low bone mineral density,” Bone, vol. 46, no. 3, pp. 747–751, 2010.
- D. T. Baran, “Thyroid hormone and bone mass: the clinician's dilemma,” Thyroid, vol. 4, no. 2, pp. 143–144, 1994.
- L. Sun, T. F. Davies, H. C. Blair, E. Abe, and M. Zaidi, “TSH and bone loss,” Annals of the New York Academy of Sciences, vol. 1068, no. 1, pp. 309–318, 2006.
- E. Abe, R. C. Marians, W. Yu et al., “TSH is a negative regulator of skeletal remodelling,” Cell, vol. 115, pp. 151–162, 2003.
- L. Sun, S. Vukicevic, R. Baliram et al., “Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 11, pp. 4289–4294, 2008.
- H. Hase, T. Ando, L. Eldeiry et al., “TNFα mediates the skeletal effects of thyroid-stimulating hormone,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 34, pp. 12849–12854, 2006.
- K. Yamoah, A. Brebene, R. Baliram et al., “High-mobility group box proteins modulate tumor necrosis factor-α expression in osteoclastogenesis via a novel deoxyribonucleic acid sequence,” Molecular Endocrinology, vol. 22, no. 5, pp. 1141–1153, 2008.
- G. Mazziotti, F. Sorvillo, M. Piscopo et al., “Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma,” Journal of Bone and Mineral Research, vol. 20, no. 3, pp. 480–486, 2005.
- M. Giusti, F. Cecoli, C. Ghiara et al., “Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-kappaBeta ligand in patients under evaluation for differentiated thyroid carcinoma,” Hormones, vol. 6, no. 4, pp. 304–313, 2007.
- G. Martini, L. Gennari, V. De Paola et al., “The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels,” Thyroid, vol. 18, no. 4, pp. 455–460, 2008.
- T. K. Sampath, P. Simic, R. Sendak et al., “Thyroid-stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats,” Journal of Bone and Mineral Research, vol. 22, no. 6, pp. 849–859, 2007.