PADI4 Haplotypes in Association with RA Mexican Patients, a New Prospect for Antigen Modulation

Table 3

Genotypic and allelic frequencies of PADI4_89, PADI4_90, and PADI4_92 SNPs of PADI4 gene in controls (HC 𝑛=98) and rheumatoid arthritis (RA 𝑛=86) patients.

SNPs	Genotypes	RA	HC	Allele	RA	HC	P	OR (95% CI)
PADI4_89	A/A	0.148	0.305	A	0.488	0.581	0.040	2.51 (1.19–5.32)
	A/G	0.679	0.551	G	0.512	0.419
	G/G	0.173	0.144
PADI4_90	C/C	0.136	0.278	C	0.420	0.562	0.004	2.64 (1.21–5.75)
	C/T	0.568	0.567	T	0.580	0.438
	T/T	0.296	0.155
PADI4_92	C/C	0.086	0.165	C	0.438	0.454	0.732	2.08 (0.81–5.36)
	C/G	0.704	0.578	G	0.562	0.546
	G/G	0.210	0.257

SNP: single nucleotide polymorphism, HC: healthy controls, RA: rheumatoid arthritis, OR: odds ratio, and 95% CI: 95% confidence interval.
In order to compute OR (95% CI), the following alleles were used as reference: PADI4_89 allele A, PADI4_90 allele C, and PADI4_92 allele C in correspondence with the nonsusceptibility haplotype (ACC).