Journal of Immunology Research

Clinical Study

Assessment of T Regulatory Cells and Expanded Profiling of Autoantibodies May Offer Novel Biomarkers for the Clinical Management of Systemic Sclerosis and Undifferentiated Connective Tissue Disease

Table 4

Peripheral lymphocyte subsets including T reg cells in patients and controls.
Lymphocyte subsets
Diagnosis CD3+
n/mmc
median value
range		CD3+CD4+
n/mmc
median value
range		CD3+CD8+
n/mmc
median value
range		CD19+
n/mmc
median value
range		CD16+CD56+
n/mmc
median value
range		CD4/CD8
ratio
median value
range		CD4/CD25/FoxP3
% of CD4+ cells
median value
range
lcSSc 1538* 1004–2666 1196* 
683–1939 		351
221–727 		250
99–763 		162
54–475 		3.05* 
1.88–4.53 		1.67* 
1.21–3.27
dcSSc 1704* 
952–3426 		1317* 
592–2637 		506
170–938 		159
45–1031 		158
90–752 		2.99
1.11–7.1 		1.85* 
1.22–3.21
UCTD1308
490–2506 		967
282–1830 		437
143–694 		181
36–866 		186
25–397 		2.30
0.56–5.11 		2.90
0.4–4.90
CTRLS1160
1300–1680 		840
738–1040 		504
272–760 		231
100–310 		294
100–810 		2.10
1.2–2.9 		2.10
1.1–3.2
<0.00010.0003 0.0800 0.0440 0.0860 0.0007 0.0030