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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 401623, 6 pages
http://dx.doi.org/10.1155/2013/401623
Clinical Study

Platelets and Inflammatory Markers in Patients with Gastric Cancer

1Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, J. Waszyngton 15a, 15-269 Bialystok, Poland
2Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowska-Curie 24a, 15-264 Bialystok, Poland
3Department of Haematological Diagnostics, Medical University of Bialystok, J. Waszyngton 15a, 15-269 Bialystok, Poland

Received 15 November 2012; Revised 5 February 2013; Accepted 17 February 2013

Academic Editor: Mario Clerici

Copyright © 2013 Joanna Matowicka-Karna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the study was to assess the contribution of platelets and inflammatory markers in gastric cancer. We studied 50 patients. Taking into consideration the advancement of gastric cancer, patients were divided into 3 groups. Group (E)—13 patients with early gastric cancer, group (A)—18 patients with regionally advanced cancer, and group (M)—19 patients with metastatic cancer. The determinations were performed twice prior to surgery and after surgery. In patients with gastric cancer, there is an increase in IL-6 and IL-23 compared with the healthy group. The highest values of IL-6 were obtained in early cancer (more than 8-fold increase), which seems to confirm the presence of acute inflammation. The lowest value of both of these cytokines was obtained in patients with metastatic cancer. In all patients, regardless of tumor stage, there was an increase in the concentration of CRP. An increase of PLT, higher proportion of the percentage of large platelets (LPLT), and increased mean platelet volume (MPV) were observed in the process of disease development. A positive correlation between MPV and LPLT and the accompanying decrease in the concentration of proinflammatory cytokines indicates the presence of an existing relationship between the platelet morphological parameters and the inflammation process in the development of gastric cancer.