Human Monoclonal Antibody-Based Therapy in the Treatment of Invasive Candidiasis

Table 3

In vitro and in vivo final evaluations of the efficacy of Mycograb and its C28Y variant.

	In vitro		In vivo
	Intrinsic fungicidal activity (MIC)	Combination therapy with AMB (CB)	Intrinsic fungicidal activity (MIC)	Combination therapy with AMB (I.C.)
Original; Mycograb	present	synergy	present	effective
Mycograb C28Y Variant	absent	synergy	absent	non effective

(CB): checkerboard assay; (I.C.): invasive candidiasis on a mouse model of systemic infection; (MIC): minimal inhibitory concentration.