Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection

Table 3

Proportions of infiltrating lymphocytes and HLA-DR expression in BKVN and AR.

	BKVN (𝑛=22)	AR (𝑛=31)	𝑃  value
CD3/total (%)	37.6±7.8	51.2±16.1	<0.001
CD4/total (%)	20.5±5.0	27.3±11.0	0.004
CD8/total (%)	18.4±4.4	23.9±8.0	0.005
CD20/total (%)	16.9±12.6	7.3±9.2	0.002
CD68/total (%)	45.5±12.4	41.4±16.0	0.324
CD3/CD68	0.97±0.61	1.84±2.36	0.059
CD3/CD20	3.88±3.79	12.76±7.96	<0.001
CD3/CD20 > 5	5	25	<0.001
CD3/CD20 > 10	2	15	0.003
HLA-DR ≥ 10%	11	22	0.156

BKVN: BK virus nephropathy; AR: acute rejection; SF: stable allograft function; HLA: human lymphocyte antigen.