Posttransplant Lymphoproliferative Disease after Lung Transplantation

Figure 1

This proposed model of pathogenesis shows EBV infection of B cells (1), concurrent immunosuppression of plasmacytoid dendritic cells, PDCs, (2), net increase in IL-10, release of α-interferon and γ-interferon, and stimulation of cytotoxic T lymphocytes and NK cells (3), and B cell lymphoproliferation (4). From [16].