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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 435672, 10 pages
Research Article

The Effect of Perioperative Immunonutrition on the Phagocytic Activity of Blood Platelets in Advanced Gastric Cancer Patients

12nd Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24A Street, 15-276 Bialystok, Poland
2Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland

Received 27 August 2013; Revised 24 October 2013; Accepted 7 November 2013

Academic Editor: Xiao-Feng Yang

Copyright © 2013 Zbigniew Kamocki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aims. Perioperative immunonutrition can influence the phagocytic activity of platelets in advanced gastric cancer. Methods. 51 patients with stage IV gastric cancer divided into four groups depending on the clinical status and 40 normal donors were analyzed. Patients of groups I and II underwent palliative gastrectomy. Patients of groups III and IV had exploratory laparotomy. Perioperative immunonutrition was administered as follows: group I—TPN, II—oral arginine, peripheral TPN, III—TPN preoperatively, and IV—without nutrition. The phagocytic activity of blood platelets was determined before and after nutritional therapy and was assessed by measuring the fraction of phagocytic thrombocytes (%phag) and the phagocytic index (Ixphag). Results. The percentage of phagocytizing platelets and the phagocytic index prior to and after the surgery amounted to the following: group I—1.136–1.237, , and 1.007–1.1, respectively, II—1.111–1.25, , and 1.011–1.083, , III—1.112–1.186, , and 0.962–1.042, , and IV—1.085–0.96, , and 1.023–1.04, . Conclusions. The phagocytic activity of platelets in patients with advanced gastric cancer is significantly impaired. Perioperative immunonutrition with oral arginine-rich diet can partially improve the phagocytic activity of blood platelets. This trial is registred with Clinicaltrials.gov-NCT01704664.