Structural and Antigenic Definition of Hepatitis C Virus E2 Glycoprotein Epitopes Targeted by Monoclonal Antibodies

Table 2

Synopsis of broadly anti-HCV/E2 neutralizing mAbs.

mAb	Origin	Epitope	Genotype breadth of neutralization (HCVpp)	Genotype breadth of neutralization (HCVcc)	In vivo  tested	Escape generation	References
9/27	Rat	Linear	1a	1a, 2a	No	N.D.	[3, 28, 32]
HCV-AB68	Human	Conformational	1b	N.D.	Yes	Yes	[33]
AP33 (MRCT10.v362)	Murine (humanized)	Linear	1–6	1a, 2a	Yes	Yes	[34–36]
3/11	Rat	Linear	1, 2, 4, 5, 6	1a, 2a	No	N.D.	[3, 28]
2/69a	Rat	Conformational	1a, 2a	1a	No	N.D.	[3, 28, 37]
11/20	Rat	Conformational	1	N.D.	No	N.D.	[3, 28]
1/39	Rat	Conformational	1	N.D.	No	N.D.
H77.16	Murine	Conformational	N.D.	1a	No	N.D.	[38]
H77.39	Murine	Conformational	N.D.	1a	No	N.D.
J6.36	Murine	Conformational	N.D.	2a	No	N.D.
J6.103	Murine	Conformational	N.D.	2a	No	N.D.
HCV1	Human	Linear	1a, 1b, 2b, 3a, 4a	2a	Yes	Yes	[39]
#8	Murine	Conformational	N.D.	1a	No	N.D.	[40, 41]
HC-1	Human	Conformational	1a, 1b	2a	No	No	[42]
HC-11	Human	Conformational	N.D.	2a	No	Yes
CBH-5	Human	Conformational	1–6	2a, 2b	No	N.D.	[43, 44]
CBH-7	Human	Conformational	1, 2, 4	2a, 2b	No	N.D.
A8	Human	Conformational	1–6	2a	No	N.D.	[45]
1:7	Human	Conformational	1–6	2a	No	N.D.
AR2A	Human	Conformational	1a, 2a, 2b, 4, 5	No	No	N.D.	[46]
AR3A	Human	Conformational	1–6	1–6	Yes	N.D.	[26, 46]
AR3B	Human	Conformational	1a, 1b, 2a, 2b, 4, 5	2a	Yes	N.D.	[46]
AR3C	Human	Conformational	1a, 1b, 2a, 2b, 4, 5	2a	No	N.D.
AR3D	Human	Conformational	1a, 1b, 2a, 2b, 4, 5	2a	No	N.D.
AR4A	Human	Conformational	1–6	1–6	Yes	N.D.	[26]
AR5A	Human	Conformational	1a, 1b, 4, 5, 6	1a, 2a, 4, 5, 6	No	ND
HC33.1	Human	Linear	N.D.	1a–6a	No	N.D.	[47]
HC33.4	Human	Linear	N.D.	1a–6a	No	N.D.
HC33.8	Human	Linear	N.D.	1a, 2a, 4a	No	N.D.
HC33.29	Human	Linear	N.D.	1a, 2a, 4a	No	N.D.
mu5B3 (hu5B3.v3)	Murine (humanized)	Linear	1a, 1b, 2a	2a	No	Yes	[36]
HC84-1	Human	Conformational	1a	1a–6a	No	No	[48]
HC84-27	Human	Conformational	1a	1a–6a	No	No
e20	Human	Conformational	1a, 1b, 2a, 2b, 4, 5 (N.D. on 3 and 6)	1a, 2a	No	N.D.	[49–51]
e137	Human	Conformational	1a, 1b, 2a, 2b, 4, 5 (N.D. on 3 and 6)	1a, 2a	No	N.D.	[50–52]

ND: not determined.