An Innovative Method to Identify Autoantigens Expressed on the Endothelial Cell Surface: Serological Identification System for Autoantigens Using a Retroviral Vector and Flow Cytometry (SARF)

Table 2

Reported target antigens of anti-endothelial cell antibodies.

Disease	Target antigen	Pathogenicity
Systemic lupus erythematosus	DNA-DNA-histone
	Ribosomal P protein PO
	Ribosomal protein L6
	Elongation factor 1-alpha
	Adenylyl cyclase-associated protein
	Profilin 2
	Plasminogen activator inhibitor
	Fibronectin
	Heparan sulfate
	β2-glycoprotein I
	Heat-shock protein 60 (Hsp 60)	Apoptosis
	Heat-shock protein 70 (Hsp 70)
	Fibronectin leucine-rich transmembrane protein 2 (FLRT2)	Complement-dependent cytotoxicity
Mixed connective tissue disease	Voltage-dependent anion-selective channel 1 (VDAC-1)
Systemic sclerosis	Topoisomerase I
	Centromere protein B (CENP-B)
Vasculitis	Proteinase 3
	Myeloperoxidase
	Peroxiredoxin 2	Cytokine secretion
	Adenosine triphosphate (ATP) synthase	Intracellular acidification
Microscopic polyangiitis	Human lysosomal-associated membrane protein 2
Behçet's disease	Alpha-enolase
	C-terminus of Ral-binding protein 1 (RLIP76)	Apoptosis
Kawasaki disease	Tropomyosin
	T-plastin
Transplantation	Vimentin
	Keratin-like protein
Thrombotic thrombocytopenic purpura	Glycoprotein CD36
Heparin-induced thrombocytopenia	Platelet factor 4 (PF4)
	Heparin sulfate