Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

Table 3

Comparison of correlations among CD127 expression on CD4+ (first part of the table) and CD8+ (middle part of the table) T-cells and frequencies of CD4+CD25+CD127− T-cells (last part of the table) and metabolic, inflammatory, and vascular/endothelial parameters in children with long-lasting T1D.

Correlations of CD127 MFI on CD4+ T-cells	P value, R
CD127 MFI versus age	𝑃=0.48, 𝑅=0.13
CD127 MFI versus duration of disease	𝑃=0.34, 𝑅=0.17
CD127 MFI versus current HbA1c	𝑃=0.47, 𝑅=0.13
CD127 MFI versus mean HbA1C (from last 6 months)	𝑃=0.20, 𝑅=0.23
CD127 MFI versus BMI	𝑃=0.15, 𝑅=0.26
CD127 MFI versus mean SBP	𝑃=0.89, 𝑅=−0.02
CD127 MFI versus mean DBP	𝑃=0.19, 𝑅=0.23
CD127 MFI versus white blood cells	𝑃=0.30, 𝑅=−0.21
CD127 MFI versus hsCRP	𝑃=0.18, 𝑅=−0.28
CD127 MFI versus VE-cadherin	𝑃=0.67, 𝑅=−0.09
CD127 MFI versus angiopoietin	𝑃=0.07, 𝑅=0.37
CD127 MFI versus VEGF	𝑃=0.32, 𝑅=−0.21
CD127 MFI versus IMT	𝑃=0.93, 𝑅=0.02
CD127 MFI versus FMD	𝑃=0.88, 𝑅=−0.03
CD127 MFI versus cholesterol	𝑃=0.07, 𝑅=0.32
CD127 MFI versus LDL	𝑃=0.10, 𝑅=0.30
CD127 MFI versus HDL	𝑃=0.48, 𝑅=0.13
CD127 MFI versus TG	𝑃=0.27, 𝑅=0.20
CD127 MFI versus % of CD34+CD309+ cells	𝑃=0.37, 𝑅=−0.19
CD127 MFI versus % of CD34+CD144+ cells	𝑃=0.88, 𝑅=0.03
CD127 MFI versus % of CD4+CD25− T-cells	𝑃=0.94, 𝑅=−0.01
Correlations of CD127 MFI on CD8+ T-cells	P value, R
CD127 MFI versus age	𝑃=0.16, 𝑅=0.30
CD127 MFI versus duration of disease	𝑃=0.48, 𝑅=−0.15
CD127 MFI versus current HbA1c	𝑃=0.96, 𝑅=0.01
CD127 MFI versus mean HbA1C (from last 6 months)	𝑃=0.70, 𝑅=−0.09
CD127 MFI versus BMI	𝑃=0.43, 𝑅=0.17
CD127 MFI versus mean SBP	𝑃=0.88, 𝑅=0.03
CD127 MFI versus mean DBP	𝑃=0.91, 𝑅=0.03
CD127 MFI versus white blood cells	𝑃=0.69, 𝑅=0.09
CD127 MFI versus hsCRP	𝑃=0.94, 𝑅=−0.02
CD127 MFI versus VE-cadherin	𝑃=0.12, 𝑅=−0.36
CD127 MFI versus angiopoietin	𝑃=0.05, 𝑅=0.44
CD127 MFI versus VEGF	P = 0.04, R = 0.46
CD127 MFI versus IMT	𝑃=0.44, 𝑅=−0.19
CD127 MFI versus FMD	𝑃=0.37, 𝑅=−0.22
CD127 MFI versus cholesterol	𝑃=0.47, 𝑅=0.16
CD127 MFI versus LDL	𝑃=0.47, 𝑅=0.16
CD127 MFI versus HDL	𝑃=0.20, 𝑅=−0.28
CD127 MFI versus TG	P < 0.05, R = 0.43
CD127 MFI versus % of CD34+CD309+ cells	𝑃=0.60, 𝑅=0.13
CD127 MFI versus % of CD34+CD144+ T-cells	𝑃=0.89, 𝑅=−0.03
CD127 MFI versus % of CD4+CD25− T-cells	𝑃=0.75, 𝑅=0.07
Correlations of % of CD4+CD25+CD127− T-cells	P value, R
% of CD4+CD25+CD127− T-cells versus age	𝑃=0.32, 𝑅=0.18
% of CD4+CD25+CD127− T-cells versus duration of disease	𝑃=0.11, 𝑅=0.28
% of CD4+CD25+CD127− T-cells versus current HbA1c	𝑃=0.23, 𝑅=0.22
% of CD4+CD25+CD127− T-cells versus mean HbA1C (from last 6 months)	𝑃=0.30, 𝑅=0.19
% of CD4+CD25+CD127− T-cells versus BMI	𝑃=0.62, 𝑅=0.09
% of CD4+CD25+CD127− T-cells versus mean SBP	P = 0.04, R = 0.35
% of CD4+CD25+CD127− T-cells versus mean DBP	𝑃=0.52, 𝑅=0.12
% of CD4+CD25+CD127− T-cells versus white blood cells	𝑃=0.90, 𝑅=−0.03
% of CD4+CD25+CD127− T-cells versus hsCRP	𝑃=0.99, 𝑅=0.00
% of CD4+CD25+CD127− T-cells versus VE-cadherin	𝑃=0.78, 𝑅=−0.06
% of CD4+CD25+CD127− T-cells versus angiopoietin	𝑃=0.47, 𝑅=−0.15
% of CD4+CD25+CD127− T-cells versus VEGF	𝑃=0.84, 𝑅=0.04
% of CD4+CD25+CD127− T-cells versus IMT	𝑃=0.61, 𝑅=0.11
% of CD4+CD25+CD127− T-cells versus FMD	𝑃=0.90, 𝑅=0.03
% of CD4+CD25+CD127− T-cells versus cholesterol	𝑃=0.68, 𝑅=0.07
% of CD4+CD25+CD127− T-cells versus LDL	𝑃=0.60, 𝑅=0.10
% of CD4+CD25+CD127− T-cells versus HDL	𝑃=0.36, 𝑅=−0.17
% of CD4+CD25+CD127− T-cells versus TG	𝑃=0.57, 𝑅=−0.10
% of CD4+CD25+CD127− T-cells versus % of CD34+CD309+ cells	𝑃=0.39, 𝑅=0.18
% of CD4+CD25+CD127− T-cells versus % of CD34+CD144+ cells	P = 0.04, R = 0.43
% of CD4+CD25+CD127− T-cells versus % of CD4+CD25− T-cells	P < 0.001, R = −0.81

SBP: systolic blood pressure; DBP: diastolic blood pressure; VEGF: vascular endothelial growth factor; IMT: intimamedia thickness; FMD: flow-mediated dilation; LDL: low density lipoproteins; HDL: high density lipoproteins; TG: triglycerides. Statistically significant correlations are indicated in bold font.