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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 474028, 9 pages
http://dx.doi.org/10.1155/2013/474028
Clinical Study

Higher Levels of Autoantibodies Targeting Mutated Citrullinated Vimentin in Patients with Psoriatic Arthritis Than in Patients with Psoriasis Vulgaris

1Department of Dermatology and Allergology, University of Szeged, 6 Korányi Fasor, Szeged 6720, Hungary
2Department of Rheumatology, University of Szeged, 57 Kálvária Sugárút, Szeged 6725, Hungary
3Erzsébet Hospital, Hódmezővásárhely, Rheumatology and Rehabilitation Center of Kakasszék, 143 IV. Kerület, Székkutas 6821, Hungary
4Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, 6 Korányi Fasor, Szeged 6720, Hungary

Received 12 October 2012; Revised 23 December 2012; Accepted 2 January 2013

Academic Editor: Xavier Bossuyt

Copyright © 2013 Szandra Dalmády et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antibodies against citrullinated proteins/peptides (ACPAs), and especially antibodies targeting mutated citrullinated vimentin (anti-MCVs), are novel biomarkers of rheumatoid arthritis (RA). Whereas ACPAs are specific and sensitive markers for RA, there have hardly been any reports relating to ACPAs in psoriatic arthritis (PsA) or in psoriasis without joint symptoms (PsO). The aim of the present study was to investigate the prevalence of anti-MCVs in PsA and PsO. Serum anti-MCV titers were measured in 46 PsA and 42 PsO patients and in 40 healthy controls by means of a commercial enzyme-linked immunosorbent assay. The potential correlations of the serum autoantibody levels with several clinical and laboratory parameters were examined. The anti-MCV levels in the PsA patients were significantly higher than those in the PsO group. Among the clinical variables, the presence of tender knee joints and nail psoriasis was significantly associated with anti-MCV positivity in the PsA patients. Higher anti-MCV titers in the PsO patients were associated with a more severe disease course and with the early onset of psoriatic skin symptoms. Our results suggest that anti-MCVs can be used as novel markers in the diagnosis of PsA and in a subset of PsO patients.