Higher Levels of Autoantibodies Targeting Mutated Citrullinated Vimentin in Patients with Psoriatic Arthritis Than in Patients with Psoriasis Vulgaris
Table 3
Comparisons of clinical findings in anti-MCV-positive and anti-MCV-negative PsA patients.
Variable
Anti-MCV-positive PsA patients (N = 11)
Anti-MCV-negative PsA patients (N = 35)
Sex ratio (male : female)
3 : 8
21 : 14
Age (mean ± SD; years)
57.91 ± 9.26
53.23 ± 12.48
Current smoker (%)
9
23
Age at diagnosis of PsO (mean ± SD; years)
44.27 ± 13.73
37.23 ± 14.48
Age at diagnosis of PsA (mean ± SD; years)
46.55 ± 15.78
44.86 ± 13.34
PsA severity (mild : moderate to severe)
0 : 11
0 : 35
Psoriasis guttata (%)
9
3
Arthritis mutilans
9
0
Axial type (%)
27
14
Distal type (%)
9
3
Asymmetrical oligoarthritis (%)
64
51
Symmetrical polyarthritis (%)
36
46
Therapy
Received local steroid treatment (%)
73
83
Received sulfasalazine (%)
27
20
Received systemic steroid treatment (%)
27
9
Received 311 nm NB-UVB therapy (%)
18
3
Received PUVA therapy (%)
0
3
Received MTX therapy (%)
73
89
Received biological therapy (%)
18
11
DIP involvement (%)
18
37
Erosion (%)
18
26
Level of anti-MCV (mean ± SD; U/mL)
102.41 ± 150.99
7.67 ± 3.77
*
ANA positivity (%)†
50
33
RF positivity (%)†
0
14
DAS28 score (mean ± SD)
4.49 ± 0.98
4.52 ± 1.02
Psoriatic skin lesions
Nail psoriasis (%)
64
17
*
Scalp psoriasis (%)
64
74
Plaques on the face (%)
9
11
Plaques on the upper limbs (%)
55
63
Plaques on the trunk (%)
36
29
Plaques on the perineum (%)
9
17
Plaques on the lower limbs (%)
55
60
Arthritic features
Tender joint count (mean ± SD)
7.27 ± 3.58
10.57 ± 6.29
Back (%)
36
51
Shoulders (%)
36
37
Elbows (%)
18
14
Wrists (%)
45
46
Hands (%)
45
74
Hips (%)
0
23
Knees (%)
64
26
*
Feet (%)
73
57
Swollen joint count (mean ± SD)
3.45 ± 2.94
2.43 ± 3.27
Swollen shoulder (%)
0
0
Swollen elbow (%)
9
0
Swollen wrist (%)
18
6
Hand joints (%)
45
40
Swollen knee (%)
27
6
Feet joints (%)
18
29
PsO: psoriasis vulgaris, PsA: psoriatic arthritis, anti-MCVs: antibodies against mutated citrullinated vimentin, BMI: body mass index, PASI: psoriasis area and severity index, DAS28: disease activity score, DIP: distal interphalangeal, HLA B27: human leukocyte antigen B27, ANA: anti-nuclear antibodies, RF: rheumatoid factor, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, MTX: methotrexate, PUVA: psoralen + ultraviolet A, nm: nanometer. Symmetrical arthritis: bilateral arthritis with a frequency of >50%. †The current values in these cases related to at least in 60%. For the other values, the data were complete: 100%. *There were significant differences between the anti-MCV-positive and negative groups ( < 0.05).
