Research Article
B Epitope Multiplicity and B/T Epitope Orientation Influence Immunogenicity of Foot-and-Mouth Disease Peptide Vaccines
| Peptide
name | FMDV protein (residues) | Structure* |
| | B | VP1 (136–154) | PVTNVRGDLQVLAQKAART |
| | T | 3A (21–35) | AAIEFFEGMVHDSIK |
| | BT | VP1 (136–154)-3A (21–35) | PVTNVRGDLQVLAQKAARTAAIEFFEGMVHDSIK |
| | TB | 3A (21–35)-VP1 (136–154) | AAIEFFEGMVHDSIKPVTNVRGDLQVLAQKAART |
| | B2T | [VP1 (136–154)]2-3A (21–35) |  |
| | B4T | [VP1 (136–154)]4-3A (21–35) |  |
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All peptides in C-terminal carboxamide form. The arrow in B2T and B4T structures indicates a putative cathepsinD cleavage site [21].
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