Role of Toll-Like Receptor 4 on Lupus Lung Injury and Atherosclerosis in LPS-Challenge ApoE^−/− Mice

Figure 3

Effects of LPS and TAK-242 on brachiocephalic artery intima-media thickness or aortic sinus plaques. Specimens of HE staining under fluorescence microscopy depicted thickened IMT (arrow) in LPS-treated vessel compared to control artery ((a)–(f), 400x). And HE staining indicated no obvious changes of aortic sinus plaques in ApoE^−/− mice ((g)–(i), 100x). NS: physiological saline; LPS: lipopolysaccharide; TAK-242: resatorvid.

(a) Wild-type NS

(b) Wild-type LPS

(c) Wild-type LPS + TAK-242

(d) ApoE^−/− NS

(e) ApoE^−/− LPS

(f) ApoE^−/− LPS + TAK-242

(g) ApoE^−/− NS

(h) ApoE^−/− LPS

(i) ApoE^−/− LPS + TAK-242