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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 482691, 7 pages
http://dx.doi.org/10.1155/2013/482691
Clinical Study

Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis

1Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C/Celestino Villamil s/n, Oviedo, 33006 Asturias, Spain
2Psoriasis Unit, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain
3Dermatology Department, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain
4Clinical Epidemiology Unit, BIODONOSTIA, San Sebastian, Basque Country, Spain
5Department of Functional Biology, Oviedo University School of Medicine, Oviedo, Asturias, Spain
6Immunology Service, HUCA, Oviedo, Asturias, Spain

Received 16 September 2012; Revised 17 March 2013; Accepted 28 March 2013

Academic Editor: Chung Tei Chou

Copyright © 2013 Rubén Queiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Castelino and A. Barton, “Genetic susceptibility factors for psoriatic arthritis,” Current Opinion in Rheumatology, vol. 22, no. 2, pp. 152–156, 2010. View at Publisher · View at Google Scholar
  2. J. Martínez-Borra, C. Brautbar, S. González, C. D. Enk, A. López-Vázquez, and C. López-Larrea, “The region of 150 kb telometic to HLA-C is associated with psoriasis in the Jewish population,” Journal of Investigative Dermatology, vol. 125, no. 5, pp. 928–932, 2005.
  3. J. Martínez-Borra, S. González, J. Santos-Juanes et al., “Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C,” Rheumatology, vol. 42, no. 9, pp. 1089–1092, 2003. View at Publisher · View at Google Scholar
  4. D. D. Gladman, C. Antoni, P. Mease, D. O. Clegg, and O. Nash, “Psoriatic arthritis: epidemiology, clinical features, course, and outcome,” Annals of the Rheumatic Diseases, vol. 64, no. 2, pp. ii14–ii17, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. G. M. Alenius, B. Stenberg, H. Stenlund, M. Lundblad, and S. R. Dahlqvist, “Inflammatory joint manifestations are prevalent in psoriasis: prevalence study of joint and axial involvement in psoriatic patients, and evaluation of a psoriatic and arthritic questionnaire,” Journal of Rheumatology, vol. 29, no. 12, pp. 2577–2582, 2002. View at Scopus
  6. S. Gonzalez, J. Martinez-Borra, J. C. Torre-Alonso et al., “The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis,” Arthritis and Rheumatism, vol. 42, no. 5, pp. 1010–1016, 1999.
  7. S. González, J. Martínez-Borra, A. López-Vázquez, S. García-Fernández, J. C. Torre-Alonso, and C. López-Larrea, “MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis,” Journal of Rheumatology, vol. 29, no. 5, pp. 973–978, 2002.
  8. S. González, C. Brautbar, J. Martínez-Borra et al., “Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish population,” Human Immunology, vol. 62, no. 6, pp. 632–638, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Lee, J. D. Reveille, J. C. Davis Jr., T. J. Learch, M. M. Ward, and M. H. Weisman, “Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort,” Annals of the Rheumatic Diseases, vol. 66, no. 5, pp. 633–638, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Eder, A. Thavaneswaran, V. Chandran, and D. D. Gladman, “Gender related differences in severity of psoriatic arthritis,” Arthritis and Rheumatism, vol. 63, supplement 10, Article ID 2486C, 2011.
  11. R. Queiro, C. Sarasqueta, J. Belzunegui, C. Gonzalez, M. Figueroa, and J. C. Torre-Alonso, “Psoriatic spondyloarthropathy: a comparative study between HLA-B27 positive and HLA-B27 negative disease,” Seminars in Arthritis and Rheumatism, vol. 31, no. 6, pp. 413–418, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Queiro, M. Alperi, A. Lopez, C. Sarasqueta, J. L. Riestra, and J. Ballina, “Clinical expression, but not disease outcome, may vary according to age at disease onset in psoriatic spondylitis,” Joint Bone Spine, vol. 75, no. 5, pp. 544–547, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. D. D. Gladman, B. Brubacher, D. Buskila, P. Langevitz, and V. T. Farewell, “Psoriatic spondyloarthropathy in men and women: a clinical, radiographic, and HLA study,” Clinical and Investigative Medicine, vol. 15, no. 4, pp. 371–375, 1992. View at Scopus
  14. W. Taylor, D. Gladman, P. Helliwell, A. Marchesoni, P. Mease, and H. Mielants, “Classification criteria for psoriatic arthritis: development of new criteria from a large international study,” Arthritis and Rheumatism, vol. 54, no. 8, pp. 2665–2673, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. J. M. H. Moll and V. Wright, “Psoriatic arthritis,” Seminars in Arthritis and Rheumatism, vol. 3, no. 1, pp. 55–78, 1973. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Tamiya, M. Ota, Y. Katsuyama et al., “Twenty-six new polymorphic microsatellite markers around the HLA-B, -C and -E loci in the human MHC class I region,” Tissue Antigens, vol. 51, no. 4, part 1, pp. 337–346, 1998. View at Scopus
  17. J. Zochling and E. U. R. Smith, “Seronegative spondyloarthritis,” Best Practice and Research: Clinical Rheumatology, vol. 24, no. 6, pp. 747–756, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Rudwaleit, “New approaches to diagnosis and classification of axial and peripheral spondyloarthritis,” Current Opinion in Rheumatology, vol. 22, no. 4, pp. 375–380, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Queiro, C. Sarasqueta, J. C. Torre, T. Tinturé, and I. López-Lagunas, “Spectrum of psoriatic spondyloarthropathy in a cohort of 100 Spanish patients,” Annals of the Rheumatic Diseases, vol. 61, no. 9, pp. 857–858, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. U. Hüffmeier, A. Reis, M. Steffens et al., “Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis,” The Journal of investigative dermatology, vol. 126, no. 4, pp. 932–935, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. J. E. Gudjonsson, A. Karason, E. H. Runarsdottir et al., “Distinct clinical differences between HLA-Cw*0602 positive and negative psoriasis patients—an analysis of 1019 HLA-C- and HLA-B-typed patients,” Journal of Investigative Dermatology, vol. 126, no. 4, pp. 740–745, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Winchester, G. Minevich, V. Steshenko et al., “HLA associations reveal genetic heterogeneity in psoriatic arthritis and in the psoriasis phenotype,” Arthritis and Rheumatism, vol. 64, no. 4, pp. 1134–1144, 2011. View at Publisher · View at Google Scholar
  23. T. Henseler and E. Christophers, “Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris,” Journal of the American Academy of Dermatology, vol. 13, no. 3, pp. 450–456, 1985. View at Scopus
  24. R. Queiro, S. Alonso, M. Alperi, M. Fernández, and C. Sarasqueta, “Stratification by age of onset with 30 years as age limit is an effective means of identifying PSORS1-associated psoriasis in patients with psoriatic arthritis,” Joint Bone Spine, vol. 78, no. 6, pp. 581–583, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Eder, V. Chandran, F. Pellet et al., “Human leucocyte antigen risk alleles for psoriatic arthritis among patients with psoriasis,” Annals of the Rheumatic Diseases, vol. 71, no. 1, pp. 50–55, 2012. View at Publisher · View at Google Scholar