Clinical Differences between Men and Women with Psoriatic Arthritis: Relevance of the Analysis of Genes and Polymorphisms in the Major Histocompatibility Complex Region and of the Age at Onset of Psoriasis

Table 2

Differences between men and women according to age at psoriasis onset (cutoff: 40 years).

(a) Age at psoriasis onset <40

Variable	Men	Women	𝑃 values
	n: 45	n: 40
Age (yr)	46.3±8.5	48.6±14.6	NS
Arthritis onset age (yr)	35.5±6.8	37.6±10.6	NS
Psoriasis onset age (yr)	25±8.2	22±9.9	NS
Psoriasis duration (yr)	16.3±14.1	21±9.2	0.07
Arthritis duration (yr)	10.9±9.5	11±8.9	NS
Psoriasis-arthritis latency (yr)	5.5±7.1	9.3±6.6	<0.01
Family history	44.4%	50%	NS
Oligoarthritis	46.7%	40%	NS
Polyarthritis	17.7%	37.5%	<0.05
Axial disease	33.3%	22.5%	NS
DIP disease	26.7%	40%	NS
Nail disease	37.8%	52.5%	NS
Enthesitis	35.6%	27.5%	NS
Dactylitis	25.5%	35%	NS
Erosive disease	33.3%	40%	NS
HAQ	0.7±4.5	0.8±6.2	NS
SJC	3.3±4.6	4.3±3.2	NS
TJC	8.2±.5.2	9.2±5.5	NS
PASI	7.3±3.4	8.1±4.4	NS

(b) Age at psoriasis onset >40

Variable	Men	Women	𝑃 values
	n: 10	n: 15
Age (yr)	59.4±8.4	67.1±8.2	0.03
Arthritis onset age (yr)	49.4±3.4	52.5±9.6	NS
Psoriasis onset age (yr)	45.7±3.4	51.2±6.9	<0.05
Psoriasis duration (yr)	13.6±8	15.9±5.3	NS
Arthritis duration (yr)	9.9±5.9	14.5±9	NS
Psoriasis-arthritis latency (yr)	3.7±3.3	3.2±3.6	NS
Family history	10%	13.3%	NS
Oligoarthritis	0%	20%	NS
Polyarthritis	30%	53.3%	NS
Axial disease	70%	33.3%	NS
DIP disease	30%	13.3%	NS
Nail disease	30%	20%	NS
Enthesitis	30%	20%	NS
Dactylitis	30%	20%	NS
Erosive disease	40%	46.7%	NS
HAQ	0.8±5.1	0.9±5.3	NS
SJC	3.2±4.6	4.7±4.4	NS
TJC	10.3±4.1	11.3±5.2	NS
PASI	4.2±2.3	3.8±3.6	NS

DIP: distal interphalangeal joint. HAQ: Health Assessment Questionnaire. SJC: swelling joint count. TJC: tender joint count. PASI: Psoriasis Area and Severity Index.