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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 510547, 7 pages
http://dx.doi.org/10.1155/2013/510547
Research Article

TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis

1Liver Research Laboratories, Pomeranian Medical University, Aleja Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland
2Liver Unit, Department of General Surgery and Liver Transplantation, Warsaw Medical University, ul. Banacha 1a, 02-097 Warsaw, Poland
3Medical Biology Laboratory, Pomeranian Medical University, Aleja Powstańców Wielkopolskich 72 70-111 Szczecin, Poland
4Institute of Liver Studies, King’s College London School of Medicine, King’s College Hospital, Denmark Hill, London SE5 9RS, UK

Received 6 March 2013; Accepted 6 April 2013

Academic Editor: Eirini I. Rigopoulou

Copyright © 2013 Joanna Raszeja-Wyszomirska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Previous studies reported associations between specific alleles of non-HLA immunoregulatory genes and higher fatigue scores in patients with primary biliary cirrhosis (PBC). Aim. To study the relationship between variables of health-related quality of life (HRQoL) and single nucleotide polymorphisms of TRAF1-C5, a member of the tumor necrosis factor receptor family. Patients and Methods. TRAF1-C5 gene polymorphisms, rs2900180 and rs3761847, were analysed in 120 Caucasian PBCs. The HRQoL was assessed with SF-36, PBC-40, and PBC-27 questionnaires. Results. We found a negative association between TT genotype of rs2900180 and SF-36’s domains vitality ( ), mental health ( ), and mental component summary score ( ). GG homozygotes of rs3761847 had lower vitality ( ), mental health ( ), mental component summary score ( ) and impairment of social functioning ( ). Allelic analysis has shown that T allele of rs2900180 and G allele of rs3761847 related to SF-36’s vitality ( and ), social functioning ( and ), mental health ( and ), and mental component summary score ( and ), respectively. Genotyping and allelic analysis did not reveal correlation with PBC-40 and PBC-27 domains. Conclusion. The association between rs2900180 and rs3761847 polymorphisms and HRQoL variables indicates that TRAF1 is involved in the induction of impaired QoL in PBC.