Review Article

Modification of Intestinal Microbiota and Its Consequences for Innate Immune Response in the Pathogenesis of Campylobacteriosis

Table 2

Cytokines induced in C. jejuni infections.

CytokinesPossible functionReferences

Chemokines: CC families: MIP-1α, MIP-1β, RANTES, and MCP-1They act as chemoattractant agents for monocytes and T-lymphocytes.[92]

Chemokines: CXC families: GRO-α, GRO-γ, IP-10, and MIGGRO-α and GRO-γ attract neutrophils to sites of inflammation. IP-10 and MIG promote the chemotaxis of monocytes and activated T-lymphocytes.[101]

Interleukins: IL-1B, IL-6, IL-8, IL-10, IL-12, IL-17A, IL-17F, IL-22, and IL-23 These chemoattractants and immune cells activators initiate Th1 and Th17 response. IL-5 and IL-6 activate STAT3. IL-22 maintains epithelial cell function and activation of macrophages.[69, 93, 96, 100, 102, 103]

Interferon-gamma (IFN-γ)[59, 69, 86, 93]

Tumor necrosis factor-alpha (TNF-α)Plays a major role in production of IL-1 and IL-6[86, 93]

Nuclear factor kappa-light-chain-enhancer (NF-κB)signal transducer and activator of transcription 3 (STAT3)Stimulates production of chemokines
limits host inflammatory response in the gut
[86, 92, 104, 105]