New Allogeneic Hematopoietic Stem Cell Transplantation Method: Hematopoietic Stem Cell Transplantation Plus Thymus Transplantation for Intractable Diseases

Figure 1

Theory of allo-HSCT + TT. In the case of conventional allo-HSCT (left), the allo-T cells develop and are tolerated in the host thymus, and no GVHD occurs. In the case of allo-HSCT + DLI (right), nontolerated allo-T cells are externally supplied, and strong GVHD is induced with reduction of T cell function. In the case of allo-HSCT + TT, the allo-T cells develop internally in the allothymus. The T cells show partial tolerance to the host, and only mild GVHD occurs with elevation of T cell function (middle).