Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma
Table 3
Correlation of HIF-2α, TWIST, and CXCR4 protein expression with clinicopathological parameters in 129 PTCs.
Characteristics
Case ()
HIF-2α
TWIST
CXCR4
Low
High
value
Low
High
value
Low
High
value
Tissue type
Normal thyroid tissue
118
118
0
118
0
118
0
Nodular hyperplasia
61
61
0
—
61
0
—
61
0
—
PTC
129
65
64
<0.001a <0.001b
73
56
<0.001
58
71
<0.001a <0.001b
Classic PTC
80
40
40
0.980
44
36
0.963
39
41
0.672
Follicular variant of PTC
21
11
10
12
9
9
12
Tall cell variant of PTC
15
7
8
9
6
5
10
Oncocytic variant of PTC
13
7
6
8
5
5
8
Age (years)
≤45
69
35
34
0.935
43
26
0.159
33
36
0.483
60
30
30
30
30
25
35
Gender
Male
32
16
16
0.960
20
12
0.437
13
19
0.570
Female
97
49
48
53
44
45
52
Tumor size (cm)
≤2.3
83
45
38
0.243
51
32
0.135
40
43
0.322
46
20
26
22
24
18
28
TNM stage
I-II
69
35
34
0.935
41
28
0.487
31
38
0.993
III-IV
60
30
30
32
28
27
33
Lymph node metastasis
Absent
61
46
15
<0.001
50
11
<0.001
40
21
<0.001
Present
68
19
49
23
45
18
50
values derived using chi-square test to compare the expression of HIF-2α, TWIST, and CXCR4 between subgroups defined by each clinicopathological parameter; asignificant difference between PTCs and normal thyroid tissues; bsignificant difference between PTCs and nodular hyperplasia. significant difference.