Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

Table 5

Correlation of concomitant expression of HIF-2α, TWIST, and CXCR4 with LNM.

		LNM
	Absent	Present	𝑃-value
HIF-2α/TWIST			<0.001^a
(1) Both HIF-2α/TWIST low expression	43 (87.8)	6 (12.2)
(2) One of HIF-2α/TWIST high expression	13 (32.5)	27 (67.5)	0.032^b
(3) Both HIF-2α/TWIST high expression	5 (12.5)	35 (87.5)
TWIST/CXCR4			<0.001^a
(1) Both TWIST/CXCR4 low expression	41 (89.1)	5 (10.9)
(2) One of TWIST/CXCR4 high expression	14 (35.9)	25 (64.1)	0.018^b
(3) Both TWIST/CXCR4 high expression	6 (13.6)	38 (86.4)
HIF-2α/CXCR4			<0.001^a
(1) Both HIF-2α/CXCR4 low expression	38 (90.5)	4 (9.5)
(2) One of HIF-2α/CXCR4 high expression	18 (46.2)	21 (53.8)	<0.001^b
(3) Both HIF-2α/CXCR4 high expression	5 (10.4)	43 (89.6)
HIF-2α/TWIST/CXCR4
Not all of HIF-2α/TWIST/CXCR4 high expression	58 (62.4)	35 (37.6)	<0.001^c
All of HIF-2α/TWIST/CXCR4 high expression	3 (8.3)	33 (91.7)

Correlation of concomitant expression of HIF-2α, TWIST, and CXCR4 with LNM were measured by chi-square test; ^asignificant difference among the three groups; ^bsignificant difference between group (2) and group (3); ^csignificant difference between groups with and without concomitant expression of all three molecules.