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Figure 2: Transcription factors in tTreg development. Once engaged, cell surface receptors initiate c-Rel activation and nuclear entry. c-Rel binding to the Foxp3 promoter and Cns elements promotes epigenetic changes, including demethylation and chromatin remodelling (not pictured) of the Foxp3 locus. Several other transcription factors cooperate with c-Rel to initiate and preserve the stable expression of Foxp3 in tTregs.