Review Article

Targeting BCL2 Family in Human Myeloid Dendritic Cells: A Challenge to Cure Diseases with Chronic Inflammations Associated with Bone Loss

Table 1

Approved Hugo gene nomenclature of the BCL2 family.

Approved symbolApproved nameActivityLocationSynonym

BCL2B-cell CLL/lymphoma 2Prosurvival18q21.3Bcl-2, PPP1R50
BCL2L1BCL2-like 1Prosurvival20q11.21Bcl-X, bcl-xL, bcl-xS,
BCL2L, BCLX, PPP1R52
BCL2L2BCL2-like 2Prosurvival14q11.2-q12BCL-W, KIAA0271, PPP1R51
MCL1Myeloid cell leukemia sequence 1
(BCL2-related)
Prosurvival1q21BCL2L3, Mcl-1
BCL2A1BCL2-related protein A1Prosurvival15q24.3ACC-1, ACC-2,
BCL2L5, BFL1, GRS
BAXBCL2-associated X proteinProapoptotic
multidomain
19q13.3-q13.4BCL2L4
BOKBCL2-related ovarian killerProapoptotic
multidomain
2q37.3BCL2L9, BOKL, MGC4631
BAK1BCL2-antagonist/killer 1Proapoptotic
multidomain
6p21.31BAK, BCL2L7
BADBCL2-associated agonist of cell deathProapoptotic
BH3-only
11q13.1BBC2, BCL2L8
BIDBH3 interacting domain death agonistProapoptotic
BH3-only
22q11.2ā€”
BCL2L11BCL2-like 11
(apoptosis facilitator)
Proapoptotic
BH3-only
2q13BIM, BimEL, BimL,
BimS, BOD
BMFBCL2 modifying factorProapoptotic
BH3-only
15q14FLJ00065
BIKBCL2-interacting killer (apoptosis-inducing)Proapoptotic
BH3-only
22q13.31NBK
HRKHarakiri, BCL2 interacting proteinProapoptotic
BH3-only
12q24.2DP5
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1Proapoptotic
BH3-only
18q21.32APR, NOXA
BBC3BCL2 binding component 3Proapoptotic
BH3-only
19q13.3-q13.4JFY1, PUMA