Impaired Lymphocyte Profile in Schistosomiasis Patients with Periportal Fibrosis

Figure 1

Strategy for T cell evaluation by flow cytometry. The cell populations were defined by nonspecific fluorescence from the forward (FSC) and side scatter (SSC) as parameters of cell size and granularity, respectively (a). Lymphocyte regions were determined through the expression of CD3-PE and CD4-PeCy7 (b) or CD3-PE and CD8-FITC (c). Frequency of TCD4⁺ cells and TCD8⁺ cells and ratio between TCD4⁺ and TCD8⁺ cells (d) in individuals infected with S. mansoni with different degrees of periportal fibrosis. Results are expressed in median, minimum, maximum, and interquartile values of frequency (*𝑃<0.05; Kruskal-Wallis test).

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