Stimulation of TLR4 by LMW-HA Induces Metastasis in Human Papillary Thyroid Carcinoma through CXCR7

Table 1

Correlation of TLR4 and CXCR7 expression with clinicopathologic features in PTC.

Clinicopathologic parameters	Case no.	TLR4 expression		𝑃 value	CXCR7 expression		𝑃 value
		Low	High		Low	High
Total cases	135	64	71	53%	102	33	24%
Age
≤60	55	27	28	𝑃=0.745	38	19	𝑃=0.080
>60	80	37	43		64	15
Tissue type
Normal tissue	56	55	1	𝑃=0.000	55	1	𝑃=0.000
Carcinoma	135	64	71		102	33
Sex
Male	65	33	32	𝑃=0.451	48	17	𝑃=0.656
Female	70	31	39		54	16
Tumor size
≤5 cm	58	39	19	𝑃=0.000	53	5	𝑃=0.000
>5 cm	77	25	52		49	28
TNM stage
I	4	4	0	𝑃=0.000	4	0	𝑃=0.005
II	65	39	26		57	8
III	38	7	31		24	14
IV	28	14	14		17	11
Histologic grade
I	8	7	1	𝑃=0.000	8	0	𝑃=0.002
II	109	56	53		86	23
III	18	1	17		8	10
Lymph nodemetastasis
Negative	76	50	26	𝑃=0.000	70	6	𝑃=0.000
Positive	59	14	45		32	27
Distant metastasis
Negative	108	56	52	𝑃=0.039	89	19	𝑃=0.000
Positive	27	8	19		13	14