Autoimmune Cytopenias in Chronic Lymphocytic Leukemia

Table 1

Reported incidence of autoimmune cytopenia complicating CLL.

Autoimmune cytopenia	Incidence
AIHA* [1–5, 7–10]	4.5–11%
ITP [1, 2, 10, 12]	2–5%
PRCA [1, 2, 6, 10]	<1%
AG [1, 2, 7, 10]	<1%

AIHA: autoimmune hemolytic anemia.
ITP: immune thrombocytopenia.
PRCA: pure red cell aplasia.
AG: autoimmune granulocytopenia.
*A positive direct antiglobulin test (DAT) without clinically evidence of hemolysis may be found in 7–14% of patients [5].