Review Article

Autoimmune Cytopenias in Chronic Lymphocytic Leukemia

Table 3

Immune defects in CLL.

T-cell
 Increased circulating number [29, 3133, 36, 39, 40]
 Decresed CD4/CD8 ratio [29, 36]
 Th2 polarization [29, 35, 36]
 Impaired immunological synapse [38]
 Increased circulating number of Tregs [39, 4144]
B-cell
 Hypogammaglobulinemia [33, 39, 40]
 Poor response to vaccination [31, 37]
NK cell
 Increased circulating number [39]
 Reduced killing activity [30, 39]
 Lack of granules [30]
Neutrophils
 Reduced phagocytic and bactericidal function [31, 32, 39]
 Abnormal migration and chemotaxis [39]