Review Article
Autoimmune Cytopenias in Chronic Lymphocytic Leukemia
Table 3
Immune defects in CLL.
| T-cell | Increased circulating number [29, 31–33, 36, 39, 40] | Decresed CD4/CD8 ratio [29, 36] | Th2 polarization [29, 35, 36] | Impaired immunological synapse [38] | Increased circulating number of Tregs [39, 41–44] | B-cell | Hypogammaglobulinemia [33, 39, 40] | Poor response to vaccination [31, 37] | NK cell | Increased circulating number [39] | Reduced killing activity [30, 39] | Lack of granules [30] | Neutrophils | Reduced phagocytic and bactericidal function [31, 32, 39] | Abnormal migration and chemotaxis [39] |
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