Autoimmune Cytopenias in Chronic Lymphocytic Leukemia

Table 4

Reported incidence of AIHA in fludarabine containing regimen treated patients with CLL.

Reference	No. of AIHA cases/no. of patients evaluated	Relative number of AIHA (%)	Type of therapy given
Di Raimondo et al. [49]	13/112	11	FAMP alone
Myint et al. [50]	12/59	21	FAMP alone
Mauro et al. [19]	3/121; 10/559	2.5; 1.8	FAMP + prednisone; Chlorambucil + prednisone
Catovsky and Richards [51]	47/387; 21/194; 9/198	12; 11; 5	Chlorambucil; FAMP; FC
Borthakur et al. [52]*	All cases; 17/300; DAT-positive; 3/300	All cases; 5.8; DAT-positive; 1.4	FCR
Hallek et al. [53]	4/249; 3/404	1%; <1%	FC; FCR

 *Three out 17 patients with AIHA had a positive-DAT, while the remaining 14 patients had a negative-test.