LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice

Figure 1

LMW heparin treatment does not affect chemokine mRNA expression within the kidneys of B/W mice. The mRNA expression of CCL2 (a), CCL7 (b), CCL20 (c), CXCL1 (d), and CXCL2 (e) was significantly increased in Group 3 mice and were not significantly reduced in heparin-treated mice. The mRNA expression of CCL2 (f), CCL7 (g), and CXCL1 (h) was also analyzed in age-matched BALB/c mice. Data is given as Log 2 of mean ± SEM of fold change values normalized against 4-week-old mice (𝑛=3). 𝑃 values are calculated using one-way ANOVA followed by Bonferroni posttest. *𝑃<0.05; **𝑃<0.01; ***𝑃<0.001. Group 1: 4–10 w.o B/W mice (𝑛=17); Group 2: 18–30 w.o B/W mice with mesangial IC deposits without proteinuria (𝑛=15); Group 3: 23–36 w.o B/W mice with proteinuria (𝑛=18); Group 4: 31–39 w.o heparin-treated B/W mice (𝑛=5).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)