Research Article

LMW Heparin Prevents Increased Kidney Expression of Proinflammatory Mediators in (NZBxNZW)F1 Mice

Table 1

Spearman correlation matrix performed on gene expression in heparin and nontreated age-matched B/W mice.

AgeHep.w. ab. Pos.Prot.CCL2CCR2CCL7CCL20CXCL1CXCL2TLR2TLR7IL1βIL10

Age0,0000,3630,4630,5170,3690,5910,6400,7140,7390,4430,3940,2710,074
Heparin1,000−0,601−0,655−0,4530,731−0,383−0,522−0,313−0,244−0,453−0,592−0,870−0,801
Weeks antibody positive0,3030,0660,6940,6770,8740,6030,8120,6520,5720,7390,8550,6220,745
Proteinuria0,1780,040 0,026 0,7980,7980,7980,7980,7980,7980,7220,7220,7980,722
CCL20,1260,1890,032 0,006 0,7450,9640,8300,6000,6360,9030,8060,6610,624
CCR20,2940,016 0,001 0,006 0,013 0,6480,8910,5270,5150,7820,8790,8300,915
CCL70,0720,2750,0650,006 <0,001 0,043 0,8180,6610,7210,7940,7210,5520,515
CCL200,046 0,1220,004 0,006 0,003 0,001 0,004 0,6850,7330,8300,9150,6970,770
CXCL10,020 0,3780,041 0,006 0,0670,1170,038 0,029 0,9640,5760,5760,4790,333
CXCL20,015 0,4970,0840,006 0,048 0,1280,019 0,016 <0,001 0,5880,5880,4420,333
TLR20,2000,1890,015 0,018 0,000 0,008 0,006 0,003 0,0820,0740,9270,7330,721
TLR70,2600,0710,002 0,018 0,005 0,001 0,019 <0,001 0,0820,074<0,001 0,7580,855
IL1β0,4490,001 0,0550,006 0,038 0,003 0,0980,025 0,1620,2000,016 0,011 0,855
IL100,8390,005 0,013 0,018 0,054<0,001 0,1280,009 0,3470,3470,019 0,002 0,002