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(a) Archetype
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(b) Mad-1
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(c) Mad-4
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(d) Mad-8
Figure 1: JCV noncoding control regions (NCCRs) containing cellular transcription factor-binding sites of archetype variant CY (a), commonly found in urine of healthy individuals and Mad-1 (b), Mad-4 (c), and Mad-8 (d) NCCR variants, illustrative of the major NCCR arrangements found in PML tissue.