Replication of British Rheumatoid Arthritis Susceptibility Loci in Two Unrelated Chinese Population Groups

Table 4

Validation of SNPs in test cohort, validation cohort, and combined analyses (combined validation cohort with test cohort).

	Genotype	Subjects number (%)		Codominant genetic model		Dominant genetic model		Recessive genetic model
		Controls	Cases	OR (95% CI)	𝑃	OR (95% CI)	𝑃	OR (95% CI)	𝑃
Test cohort rs6457617	TT	68 (37.0)	97 (52.4)	1 (ref)	—	0.53 (0.35–0.81)	0.003	0.51 (0.28–0.92)	0.025
	CT	82 (44.6)	69 (37.3)	0.59 (0.38–0.92)	0.02
	CC	34 (18.5)	19 (10.3)	0.39 (0.21–0.74)	0.004
Validation cohort rs6457617	TT	263 (35.7)	353 (48.2)	1 (ref)	—	0.60 (0.49–0.74)	𝟏.𝟓×𝟏𝟎^−𝟔	0.41 (0.30–0.56)	𝟐.𝟑×𝟏𝟎^−𝟖
	CT	340 (46.1)	319 (43.5)	0.70 (0.56–0.87)	𝟏.𝟎×𝟏𝟎^−𝟑
	CC	134 (18.2)	61 (8.3)	0.34 (0.24–0.48)	𝟓.𝟗×𝟏𝟎^−𝟏𝟎
Combined samples rs6457617	TT	331 (35.9)	450 (49.0)	1 (ref)	—	0.58 (0.48–0.70)	𝟏.𝟒×𝟏𝟎^−𝟖	0.43 (0.32–0.57)	𝟐.𝟐×𝟏𝟎^−𝟗
	CT	422 (45.8)	388 (42.3)	0.68 (0.56–0.82)	𝟏.𝟏×𝟏𝟎^−𝟒
	CC	168 (18.3)	80 (8.7)	0.35 (0.26–0.47)	𝟗.𝟒×𝟏𝟎^−𝟏𝟐

Data shown in 𝑛 (%). OR = odds ratio; 95% CI = 95% confidence interval; allele analysis and genotype analysis in dominant genetic model or in recessive genetic model for association were used by Pearson chi-square test, and genotype analyses in codominant genetic model for association were used by logistic regression.