Different Peripheral Tissue Injury Induces Differential Phenotypic Changes of Spinal Activated Microglia

Figure 3

Significant upregulation of MHC class I expression was found in the spinal cord of CCI and formalin-injected rats but weak expressed in CFA-injected rats ((a)–(d) Scale bar, 100 μm). MHC class I positive cells were colocalized with Iba-1 ((e) Scale bar, 30 μm). The intensity of MHC class I immunoreactivity was quantitatively compared among four groups (f). *𝑃<0.05, as compared with the naïve group.

(a)

(b)

(c)

(d)

(e)

(f)