An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model

<table>The v545 virus is attenuated in strain 2 guinea pigs. (a) Weight loss and DNAemia profiles were compared following inoculation of young, nonpregnant guinea pigs with v545 and control vAM403 virus. Animals inoculated with v545 gained weight throughout this postinoculation time period (mean weight gain at day 9, 40 grams) compared to animals infected with vAM403 (weight loss of 5 grams; <svg height="11.375" id="M6" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). (b) Animals challenged with v545 virus demonstrated reduced DNAemia measured at day 10 (mean viral load, 2.5 log<sub>10</sub> genomes/mL versus 3.0 log<sub>10</sub> genomes/mL in vAM403 group; <svg height="11.375" id="M7" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>).</table>

Journal of Immunology Research

fig3

Figure 3

Figure 3: An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model 

Figure 3 | An Attenuated Cytomegalovirus Vaccine with a Deletion of a Viral Chemokine Gene Is Protective against Congenital CMV Transmission in a Guinea Pig Model 