Research Article
Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy
Table 1
Clinical and biochemical characteristics of groups under study.
| | Group | | PHN | PHN-Rapa | HC | PHN versus PHN-Rapa | PHN versus HC | PHN-Rapa versus HC |
| Initial body weight (gr) | 170 ± 2.8 | 169 ± 5.2 | 180 ± 2.1 | 0.9 | 0.12 | 0.1 | Final body weight (gr) | 335.7 ± 7.3 | 268.3 ± 12.1 | 432.5 ± 9.2 | <0.001 | <0.001 | <0.001 | Kidney mass (gr) | 4.3 ± 0.3 | 2.8 ± 0.2 | 4.04 ± 0.02 | 0.001 | 0.47 | 0.009 | Kidney mass over body weight | 0.013 ± 0.0002 | 0.010 ± 0.0004 | 0.009 ± 0.0003 | 0.013 | 0.002 | 0.27 | Serum creatinine (mg/dL) | 0.30 ± 0.001 | 0.31 ± 0.03 | 0.40 ± 0.001 | 0.55 | 0.006 | 0.016 | Serum total protein (mg/dL) | 5.91 ± 0.14 | 6.33 ± 0.12 | 6.77 ± 0.075 | 0.032 | 0.001 | 0.04 | Serum albumin (mg/dL) | 2.8 ± 0.09 | 3.1 ± 0.1 | 3.6 ± 0.04 | 0.03 | 0.002 | 0.04 | Serum cholesterol (mg/dL) | 187.5 ± 21 | 313.3 ± 53 | 66 ± 5 | 0.03 | 0.05 | 0.001 |
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