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Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 959084, 5 pages
http://dx.doi.org/10.1155/2013/959084
Clinical Study

The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study

1Unidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, Guadalajara 44340, Mexico
2Doctorado en Ciencias Biomédicas, Orientación en Inmunología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, Mexico
3Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Mexico
4Departamento de Medicina Interna/Reumatología, Hospital General Regional 110 del Instituto Mexicano del Seguro Social (IMSS), 44710 Guadalajara, Mexico
5Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, Mexico
6Coordinación de Posgrado, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, Mexico
7Departamento de Fisiología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, Mexico
8División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), IMSS, 44340 Guadalajara, Mexico
9Escuela de Ciencias de la Salud, Universidad del Valle de México, Campus Zapopan, 45010 Zapopan, Mexico

Received 23 April 2013; Revised 5 August 2013; Accepted 7 August 2013

Academic Editor: George N. Goulielmos

Copyright © 2013 S. A. Zavaleta-Muñiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. There is a lack of information about the genotype frequencies of IL-6 −174G/C and −572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the association of the IL-6 −174G/C and −572G/C polymorphisms in Mexican mestizo with RA. Methods. We included 137 patients with RA and 102 healthy controls. Patients were assessed for clinical characteristics. IL-6 −174G/C and −572G/C polymorphisms were genotyped using PCR-RFLP analysis. Allele and genotype frequencies and the Hardy-Weinberg equilibrium were computed. Odds ratios (ORs) were computed to identify the risk for RA associated with the presence of GG genotype in comparison with the GC or CC genotypes. Results. The genotype −174GG occurred at a higher frequency in cases and controls (77.4% versus 78.4%, ). We found similar results for the genotype −572GG (54% in patients versus 60.8% in controls, ). Conclusions. This is the first study to evaluate the association of −174G/C and −572G/C polymorphisms of the IL-6 gene with RA in Mexican mestizo patients. These two polymorphisms were not associated with RA in the studied sample. Additional studies are required to evaluate if these IL-6 polymorphisms have relevance to the development of more severe disease.