JC Polyomavirus (JCV) and Monoclonal Antibodies: Friends or Potential Foes?

Table 1

Nonstructural and structural viral protein.

Protein	Molecular weight	No. of amino acids	Function
Early protein (transcribed counterclockwise from NCCR)
Large T antigen	79,305	688	Nonstructural protein. role in viral replication and transcription, interaction with host protein and probably in cancerogenesis
Small t antigen	20,236	172	Viral replication
Splice variants called T^′135,  T^′136,  and T^′165			Viral DNA and cancerogenesis
Late protein (transcribed clockwise from NCCR)
VP1	39,606	354	Major capsid protein, role in cellular binding and entry functions, and interaction with host receptors; it mediates hemagglutination
VP2	37,366	344	Minor capsid protein, assumed role on escape from membranous structures and nuclear import
VP3	25,743	225	Minor capsid protein assumed role on escape from membranous structures and nuclear import
Agnoprotein	8,081	71	The smaller protein that facilities capsid assembly. It is proposed as a viroporin