Significance of Semiquantitative Assessment of Preformed Donor-Specific Antibody Using Luminex Single Bead Assay in Living Related Liver Transplantation
Table 2
Results of lymphocyte crossmatch test, Mixed assay, and Single Antigen assay and histological findings and clinical outcomes in crossmatch-positive recipients.
Patient no.
LCT*
Mixed assay
MFI$ of anti-Class I HLA antibody
Mixed assay
MFI$ of anti-Class II HLA antibody
Histological findings of the first liver biopsy (POD)
C4d deposition
Outcome
Causes of death
Histological findings of the last liver biopsy in alive patients (POD)
CDC†
AHG-CDC‡
HLA-Ab class I
DSA⋀
Non-DSA
HLA-Ab class II
DSA⋀
Non-DSA
Alive/dead (POD)
1
+
+
+
High
High
−
Low
High
Cholangitis (40)
E#
Dead (118)
Sepsis
2
+
+
+
High
High
+
High
High
Cholangitis (183)
E & S**
Alive (3479)
Chronic cholangitis, possible PBC‡‡ recurrence (2360)
3
+
+
+
High
High
−
Negative
Negative
No biopsy
−
Dead (28)
Hepatic artery rupture due to biliary leakage
4
+
+
+
High
High
+
High
High
Cholestasis (18)
E & S
Dead (69)
Sepsis after repeated steroid pulse therapy for refractory ACR
5
−
+
+
High
High
+
Low
Low
No biopsy
Dead (26)
Sepsis and fungal infection after steroid pulse therapy for refractory ACR
6
−
±
+
High
High
−
Negative
Negative
No biopsy
−
Alive (1286)
No biopsy
7
−
+
+
High
High
+
Negative
Negative
Lobular inflammation (3)
E & S
Dead (49)
Intra-abdominal hemorrhage, sepsis after steroid pulse therapy for severe ACR
