Regulatory Lymphocytes Are Key Factors in MHC-Independent Resistance to EAE
Figure 3
Regulatory T cells in spleens of resistant and susceptible mice. We analyzed these cells in series of seven mice per condition. (a) We studied nonimmunized mice (NI) and mice immunized with MOG35–55 (MOG) and with PLP139–151 (PLP). CD1 mice upregulated CD4+CD25hi T cells when immunized with MOG or PLP autopeptides. Conversely, Treg percentages did not increase in C57BL/6 mice immunized with MOG that developed EAE. (b) Representative dot plots showing regulatory T cells induced in CD1 (left side) and C57BL/6 (right side) mice upon immunization with MOG35–55 peptide.
