Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity

Figure 3

The likely pathway of the “late elicitation” phase of contact hypersensitivity. The red type indicates the “early” elicitation phase and the black arrows indicate the “late” elicitation phase. Hapten-specific memory T-cells will traffic to the hapten challenge site, where they will enter the dermis and divide into multiple different cells subsets. This will be initiated by dermal APCs presenting antigen as well as cytokine release from multiple different cell subsets. The multiple subsets will play different roles in the CHS reaction at the site. Lastly, CXCR6+ hepatic NK cells will traffic to the hapten challenge site and elicit damage.