Mice Human TNF- blockers Bone-protective in inflammatory arthritis and estrogen deficiency Bone-protective in inflammatory disease Changes in bone turnover markers in postmenopause (small observational study) References: [152 –158 ] References: [17 , 19 , 20 , 159 ] IL-1 blockers Bone-protective in inflammatory arthritis and estrogen deficiency Bone-protective in RA (not usually recommended; less effective than other biologic agents) Changes in bone turnover markers in postmenopause (small observational study) References: [28 , 155 , 157 ] References: [19 , 160 , 161 ] IL-6 blockers Bone-protective in inflammatory arthritis No effects in estrogen deficiency Bone-protective in RA References: [155 , 156 , 162 , 163 ] References: [41 , 42 , 164 , 165 ] IL-17 blockers Bone-protective in inflammatory arthritis and estrogen deficiency No data in bone metabolism References: [55 , 138 , 144 , 166 , 167 ] IL-23 blockers Bone-protective in inflammatory arthritis No data References: [56 ]