Selective Depletion of Regulatory T Cell Subsets by Docetaxel Treatment in Patients with Nonsmall Cell Lung Cancer

Figure 2

aTreg cells expressed higher immunosuppressive marker CD39 in NSCLC patients and secreted suppressive cytokines. (a) PBMCs were collected from NSCLC patients. The phenotype marker of CD39 was evaluated in the three subsets of CD4⁺Foxp3⁺ Treg cells, including aTreg, non-Treg, and rTreg cells. The dot plots (left) represent the expression of CD39 in each group. The bar figures (right) represent the mean percentage of each population ± standard error of mean. (b) These cells were also stimulated in vitro and the cytokine profiles including TGF-β and IFN-γ were analyzed. ^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001 by paired 𝑡-test.

(a)  

(b)