A Micropolymorphism Altering the Residue Triad 97/114/156 Determines the Relative Levels of Tapasin Independence and Distinct Peptide Profiles for HLA-A24 Allotypes

Figure 4

Shared peptides of HLA-A24/156 allotypes. Percentages of low binding peptides shared between sHLA-A24:02, sHLA-A24:06, and sHLA-A24:13 in the presence (a) or absence (b) of TPN. Percentage of high binding peptides shared between the 3 allotypes in the presence (c) or absence (d) of TPN. (e) and (f) demonstrate percentages of low and high binding peptides shared by individual sHLA-A24/156 variants when presented in the presence and absence of TPN. sHLA-A24/156 variants in the absence of TPN were found to share a very small percentage of their overall peptide repertoire compared to peptide repertoire shared by them in the presence of TPN.

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